Supplementary ChromiumIII Propionate Complex Does Not Protect Against Insulin Resistance in High-Fat-Fed RatsReport as inadecuate

Supplementary ChromiumIII Propionate Complex Does Not Protect Against Insulin Resistance in High-Fat-Fed Rats - Download this document for free, or read online. Document in PDF available to download.

Biological Trace Element Research

, Volume 157, Issue 2, pp 147–155

First Online: 12 January 2014Received: 08 December 2013Accepted: 16 December 2013DOI: 10.1007-s12011-013-9877-3

Cite this article as: Król, E., Krejpcio, Z. & Iwanik, K. Biol Trace Elem Res 2014 157: 147. doi:10.1007-s12011-013-9877-3


Improper eating habits such as high-fat or high-carbohydrate diets are responsible for metabolic changes resulting in impaired glucose tolerance, hyperinsulinemia, insulin resistance, and ultimately diabetes. Although the essentiality of trivalent chromium for humans has been recently questioned by researchers, pharmacological dosages of this element can improve insulin sensitivity in experimental animals and diabetic subjects. The aim of the study was to assess the preventive potential of the supplementary chromiumIII propionate complex CrProp in rats fed a high-fat diet. The experiment was conducted on 32 male Wistar rats divided into four groups and fed the following diets: the control C, AIN-93G, high-fat diets HF, 40 % energy from fat, and a high-fat diet supplemented with CrProp at dosages of 10 and 50 mg Cr-kg diet HF + Cr10 and HF + Cr50, respectively. After 8 weeks, high-fat feeding led to an increased body mass, hyperinsulinemia, insulin resistance, a decreased serum urea concentration, accumulation of lipid droplets in hepatocytes, and increased renal Fe and splenic Cu contents. Supplementary CrProp in both dosages did not alleviate these changes but increased renal Cr content and normalized splenic Cu content in high-fat-fed rats. Supplementary CrProp does not prevent the development of insulin resistance in rats fed a high-fat diet.

KeywordsChromiumIII propionate complex Insulin resistance High-fat diet Rats  Download fulltext PDF

Author: Ewelina Król - Zbigniew Krejpcio - Katarzyna Iwanik


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