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BMC Biotechnology

, 13:76

Genome technology and molecular diagnostics

Abstract

The development of early and personalized diagnostic protocols is considered the most promising avenue to decrease mortality from cancer and improve outcome. The emerging microfluidic-based analyzing platforms hold high promises to fulfill high-throughput and high-precision screening with reduced equipment cost and low analysis time, as compared to traditional bulky counterparts in bench-top laboratories. This article overviewed the potential applications of microfluidic technologies for detection and monitoring of cancer through nucleic acid and protein biomarker analysis. The implications of the technologies in cancer cytology that can provide functional personalized diagnosis were highlighted. Finally, the future niches for using microfluidic-based systems in tumor screening were briefly discussed.

KeywordsMicrofluidics Diagnosis Oncology Gene Cancer biomarker AbbreviationsLOCLab-on-a-Chip

μTASmicro-total analysis systems

CAECapillary array electrophoresis

PCRPolymerase chain reaction

IHCImmunohistochemistry

MSMass spectrometry

ESIElectrospray ionization

MALDIMatrix-assisted laser desorption ionization

FACSFluorescence-activated cell sorting

MACSMagnetically-activated cell sorting

DACSDielectrophoresis DEP-activated cell sorter

FADSFluorescence-activated droplet sorter

μFCMMicrofluidic flow cytometry

WGAWhole genome amplification.

Electronic supplementary materialThe online version of this article doi:10.1186-1472-6750-13-76 contains supplementary material, which is available to authorized users.

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Author: Li Ying - Qi Wang

Source: https://link.springer.com/







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