Gamma-Linolenic Acid Levels Correlate with Clinical Efficacy of Evening Primrose Oil in Patients with Atopic DermatitisReport as inadecuate




Gamma-Linolenic Acid Levels Correlate with Clinical Efficacy of Evening Primrose Oil in Patients with Atopic Dermatitis - Download this document for free, or read online. Document in PDF available to download.

Advances in Therapy

, Volume 31, Issue 2, pp 180–188

First Online: 17 January 2014Received: 15 October 2013DOI: 10.1007-s12325-014-0093-0

Cite this article as: Simon, D., Eng, P.A., Borelli, S. et al. Adv Ther 2014 31: 180. doi:10.1007-s12325-014-0093-0

Abstract

IntroductionAtopic dermatitis AD has been related to a deficiency of delta-6-desaturase, an enzyme responsible for the conversion of linoleic acid to gamma-linolenic acid GLA. Evening primrose oil EPO contains high amounts of GLA. Therefore, this study investigated whether EPO supplementation results in an increase in plasma GLA and its metabolite dihomo-gamma-linolenic acid DGLA correlating with clinical improvement of AD, assessed by the SCORing Atopic Dermatitis SCORAD index.

MethodsThe open study included 21 patients with AD. EPO 4–6 g was administered daily for 12 weeks. Before treatment, and 4 and 12 weeks after initiation of EPO supplementation, objective SCORAD was assessed and plasma concentrations of GLA and DGLA were determined by gas chromatography.

ResultsA significant increase in plasma GLA and DGLA levels and a decrease in the objective SCORAD were observed 4 and 12 weeks after initiation of EPO treatment. In the per-protocol population n = 14, a significant inverse correlation between the changes in plasma GLA levels and SCORAD was found P = 0.008.

ConclusionThe clinical disease activity under EPO treatment correlates with the individual increase in plasma GLA levels. Thus, the results of this pilot study indicate that an increase in plasma GLA might be used as predictive parameter for responsiveness of AD to EPO therapy.

KeywordsAtopic dermatitis Dermatology Dihomo-gamma-linolenic acid Evening primrose oil Gamma-linolenic acid Omega-6 fatty acids SCORAD ClinicalTrials.gov #NCT00878670.

Electronic supplementary materialThe online version of this article doi:10.1007-s12325-014-0093-0 contains supplementary material, which is available to authorized users.

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Author: Dagmar Simon - Peter A. Eng - Siegfried Borelli - Roland Kägi - Christian Zimmermann - Catherine Zahner - Jürgen Drewe -

Source: https://link.springer.com/







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