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Science China Life Sciences

, Volume 56, Issue 10, pp 944–952

First Online: 05 September 2013Received: 07 July 2013Accepted: 20 August 2013DOI: 10.1007-s11427-013-4546-5

Cite this article as: Yang, Y., Zhou, X. & Jin, Y. Sci. China Life Sci. 2013 56: 944. doi:10.1007-s11427-013-4546-5

Abstract

Adenosine to inosine A-to-I RNA editing is the most abundant editing event in animals. It converts adenosine to inosine in double-stranded RNA regions through the action of the adenosine deaminase acting on RNA ADAR proteins. Editing of pre-mRNA coding regions can alter the protein codon and increase functional diversity. However, most of the A-to-I editing sites occur in the non-coding regions of pre-mRNA or mRNA and non-coding RNAs. Untranslated regions UTRs and introns are located in pre-mRNA non-coding regions, thus A-to-I editing can influence gene expression by nuclear retention, degradation, alternative splicing, and translation regulation. Non-coding RNAs such as microRNA miRNA, small interfering RNA siRNA and long non-coding RNA lncRNA are related to pre-mRNA splicing, translation, and gene regulation. A-to-I editing could therefore affect the stability, biogenesis, and target recognition of non-coding RNAs. Finally, it may influence the function of non-coding RNAs, resulting in regulation of gene expression. This review focuses on the function of ADAR-mediated RNA editing on mRNA non-coding regions UTRs and introns and non-coding RNAs miRNA, siRNA, and lncRNA.

KeywordsRNA editing non-coding sequence ADAR gene regulation This article is published with open access at Springerlink.com

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Author: Yun Yang - XinXin Zhou - YongFeng Jin

Source: https://link.springer.com/







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