Risk factors for cervical HPV infection and genotypes distribution in HIV-infected South Brazilian womenReport as inadecuate

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Infectious Agents and Cancer

, 9:6

Clinical oncology


BackgroundHuman Papillomavirus HPV infection is particularly burdensome for women infected with human immunodeficiency virus HIV, which increases their risk of developing cervical lesions and cancer CC. We conducted a molecular study of the distribution of cervical HPV genotypes and the risk factors for this infection in HIV-infected Brazilian women.

FindingsCervical and endocervical samples for Papanicolaou screening and HPV detection were collected from 178 HIV-infected women using highly active antiretroviral therapy HAART of Maringá city-Brazil. Risk factors were assessed using a standardized questionnaire, and the data regarding to HIV infection from medical records. HPV was detected by polymerase chain reaction PCR, and genotyping using PCR-restriction fragment length polymorphism analysis. HIV infection was well controlled, but women with a current CD4+ T lymphocyte count between 200–350 cells-mm 37.6% had a two-fold greater risk of HPV infection than those with > 350 cells-mm 26.4%. HPV was associated with parity ≥3, hormonal contraceptive use and current smoker. HPV infection occurred with high frequency 46.6% but a low frequency of cervical abnormalities was detected 7.30%, mainly low-grade squamous intraephitelial cervical lesions LSIL 84.6%. A high frequency of multiple HPV infections was detected 23.0%, and the most frequent HPV genotype was HPV-72 6.7%, followed by −16 -31 and -51 6.14% each.

ConclusionsWe showed that HAART use does not protect HIV-infected women from HPV, but appear to exert some protection against cervical lesions development. This study provides other important information about risk factors and cervical HPV in HIV-infected women, which can contribute to planning protocols.

KeywordsHIV HPV Genotypes Risk factors Cervical lesions Cervical cancer AbbreviationsHPVHuman papillomavirus

HIVHuman immunodeficiency virus

HR-HPVHigh-risk HPV

LR-HPVLow risk HPV

CCCervical cancer

SAESpecialized Assistance Service

STDSexually transmitted disease

AIDSAcquired immunodeficiency syndrome

PCRPolymerase chain reaction

LSILLow-grade squamous intraepithelial cervical lesions

ASC-UUSAtypical squamous cervical cells of undetermined significance

ASC-HAtypical squamous cervical cells could not be excluded a high-grade squamous intraepithelial cervical lesion

OpenEpiOpen source Epidemiologic Statistics for Public Health

OROdds ratio

CIConfidence interval

HAARTHighly active antiretroviral therapy.

Electronic supplementary materialThe online version of this article doi:10.1186-1750-9378-9-6 contains supplementary material, which is available to authorized users.

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Author: Sheila C Rocha-Brischiliari - Fabrícia Gimenes - André L P de Abreu - Mary M T Irie - Raquel P Souza - Rosangela G 

Source: https://link.springer.com/

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