Risk factors for cervical HPV infection and genotypes distribution in HIV-infected South Brazilian womenReport as inadecuate




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Infectious Agents and Cancer

, 9:6

Clinical oncology

Abstract

BackgroundHuman Papillomavirus HPV infection is particularly burdensome for women infected with human immunodeficiency virus HIV, which increases their risk of developing cervical lesions and cancer CC. We conducted a molecular study of the distribution of cervical HPV genotypes and the risk factors for this infection in HIV-infected Brazilian women.

FindingsCervical and endocervical samples for Papanicolaou screening and HPV detection were collected from 178 HIV-infected women using highly active antiretroviral therapy HAART of Maringá city-Brazil. Risk factors were assessed using a standardized questionnaire, and the data regarding to HIV infection from medical records. HPV was detected by polymerase chain reaction PCR, and genotyping using PCR-restriction fragment length polymorphism analysis. HIV infection was well controlled, but women with a current CD4+ T lymphocyte count between 200–350 cells-mm 37.6% had a two-fold greater risk of HPV infection than those with > 350 cells-mm 26.4%. HPV was associated with parity ≥3, hormonal contraceptive use and current smoker. HPV infection occurred with high frequency 46.6% but a low frequency of cervical abnormalities was detected 7.30%, mainly low-grade squamous intraephitelial cervical lesions LSIL 84.6%. A high frequency of multiple HPV infections was detected 23.0%, and the most frequent HPV genotype was HPV-72 6.7%, followed by −16 -31 and -51 6.14% each.

ConclusionsWe showed that HAART use does not protect HIV-infected women from HPV, but appear to exert some protection against cervical lesions development. This study provides other important information about risk factors and cervical HPV in HIV-infected women, which can contribute to planning protocols.

KeywordsHIV HPV Genotypes Risk factors Cervical lesions Cervical cancer AbbreviationsHPVHuman papillomavirus

HIVHuman immunodeficiency virus

HR-HPVHigh-risk HPV

LR-HPVLow risk HPV

CCCervical cancer

SAESpecialized Assistance Service

STDSexually transmitted disease

AIDSAcquired immunodeficiency syndrome

PCRPolymerase chain reaction

LSILLow-grade squamous intraepithelial cervical lesions

ASC-UUSAtypical squamous cervical cells of undetermined significance

ASC-HAtypical squamous cervical cells could not be excluded a high-grade squamous intraepithelial cervical lesion

OpenEpiOpen source Epidemiologic Statistics for Public Health

OROdds ratio

CIConfidence interval

HAARTHighly active antiretroviral therapy.

Electronic supplementary materialThe online version of this article doi:10.1186-1750-9378-9-6 contains supplementary material, which is available to authorized users.

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Author: Sheila C Rocha-Brischiliari - Fabrícia Gimenes - André L P de Abreu - Mary M T Irie - Raquel P Souza - Rosangela G 

Source: https://link.springer.com/







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