Small RNAs: Emerging key players in DNA double-strand break repairReport as inadecuate

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Science China Life Sciences

, Volume 56, Issue 10, pp 933–936

First Online: 11 September 2013Received: 12 August 2013Accepted: 03 September 2013DOI: 10.1007-s11427-013-4552-7

Cite this article as: Ba, Z. & Qi, Y. Sci. China Life Sci. 2013 56: 933. doi:10.1007-s11427-013-4552-7


DNA double-strand break DSB is the most deleterious form of DNA damage and poses great threat to genome stability. Eukaryotes have evolved complex mechanisms to repair DSBs through coordinated actions of protein sensors, transducers, and effectors. DSB-induced small RNAs diRNAs or Dicer-Drosha-dependent RNAs DDRNAs have been recently discovered in plants and vertebrates, adding an unsuspected RNA component into the DSB repair pathway. DiRNAs-DDRNAs control DNA damage response DDR activation by affecting DDR foci formation and cell cycle checkpoint enforcement and are required for efficient DSB repair. Here, we summarize the findings of diRNAs-DDRNAs and discuss the possible mechanisms through which they act to facilitate DSB repair.

KeywordsDNA damage small RNAs diRNA Dicer Argonaute This article is published with open access at

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Author: ZhaoQing Ba - YiJun Qi


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