Wnt6 is required for maxillary palp formation in DrosophilaReportar como inadecuado




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BMC Biology

, 11:104

First Online: 03 October 2013Received: 24 July 2013Accepted: 23 September 2013DOI: 10.1186-1741-7007-11-104

Cite this article as: Doumpas, N., Jékely, G. & Teleman, A.A. BMC Biol 2013 11: 104. doi:10.1186-1741-7007-11-104

Abstract

BackgroundWnt6 is an evolutionarily ancient member of the Wnt family. In Drosophila, Wnt6 loss-of-function animals have not yet been reported, hence information about fly Wnt6 function is lacking. In wing discs, Wnt6 is expressed at the dorsal-ventral boundary in a pattern similar to that of wingless, an important regulator of wing size. To test whether Wnt6 also contributes towards wing size regulation, we generated Wnt6 knockout flies.

ResultsWnt6 knockout flies are viable and have no obvious defect in wing size or planar cell polarity. Surprisingly, Wnt6 knockouts lack maxillary palps. Interestingly, Wnt6 is absent from the genome of hemipterans, correlating with the absence of maxillary palps in these insects.

ConclusionsWnt6 is important for maxillary palp development in Drosophila, and phylogenetic analysis indicates that loss of Wnt6 may also have led to loss of maxillary palps on an evolutionary time scale.

KeywordsDrosophila Wnt6 Maxillary palps AbbreviationsA-Panterior-posterior

D-Vdorsal-ventral

DIIdistalless

PCPplanar cell polarity

senssenseless

wgwingless.

Electronic supplementary materialThe online version of this article doi:10.1186-1741-7007-11-104 contains supplementary material, which is available to authorized users.

An erratum to this article can be found at http:-dx.doi.org-10.1186-s12915-015-0209-2.

An erratum to this article is available at http:-dx.doi.org-10.1186-s12915-015-0209-2.

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Autor: Nikolaos Doumpas - Gáspár Jékely - Aurelio A Teleman

Fuente: https://link.springer.com/



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