Allele frequency distribution of 1691G>A F5 which confers Factor V Leiden across Europe, including Slavic populationsReportar como inadecuado

Allele frequency distribution of 1691G>A F5 which confers Factor V Leiden across Europe, including Slavic populations - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Journal of Applied Genetics

, Volume 54, Issue 4, pp 441–446

First Online: 20 August 2013Received: 31 May 2013Revised: 31 July 2013Accepted: 01 August 2013DOI: 10.1007-s13353-013-0166-9

Cite this article as: Clark, J.S.C., Adler, G., Salkic, N.N. et al. J Appl Genetics 2013 54: 441. doi:10.1007-s13353-013-0166-9


The allele 1691A F5, conferring Factor V Leiden, is a common risk factor in venous thromboembolism. The frequency distribution for this allele in Western Europe has been well documented; but here data from Central, Eastern and South-Eastern Europe has been included. In order to assess the significance of the collated data, a chi-squared test was applied, and Tukey tests and z-tests with Bonferroni correction were compared. Results: A distribution with a North-Southeast band of high frequency of the 1691A F5 allele was discovered with a pocket including some Southern Slavic populations with low frequency. European countries-regions can be arbitrarily delimited into low group 1, <2.8 %, mean 1.9 % 1691A F5 allele or high group 2, ≥2.8 %, mean 4.0 % frequency groups, with many significant differences between groups, but only one intra-group difference the Tukey test is suggested to be superior to the z-tests. Conclusion: In Europe a North-Southeast band of 1691A F5 high frequency has been found, clarified by inclusion of data from Central, Eastern and South-Eastern Europe, which surrounds a pocket of low frequency in the Balkans which could possibly be explained by Slavic migration. There seem to be no indications of variation in environmental selection due to geographical location.

KeywordsAllele frequency distribution Factor V FV Leiden Tukey tests Venous thromboembolism Jeremy S. C. Clark and Grażyna Adler have an equal contribution to this work.

Download fulltext PDF

Autor: Jeremy S. C. Clark - Grażyna Adler - Nermin N. Salkic - Andrzej Ciechanowicz


Documentos relacionados