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European Journal of Nuclear Medicine and Molecular Imaging

, Volume 41, Supplement 1, pp 36–49

First Online: 17 April 2014Received: 19 December 2013Accepted: 20 December 2013DOI: 10.1007-s00259-013-2685-3

Cite this article as: Bernsen, M.R., Vaissier, P.E.B., Van Holen, R. et al. Eur J Nucl Med Mol Imaging 2014 41Suppl 1: 36. doi:10.1007-s00259-013-2685-3


Preclinical imaging with SPECT combined with CT or MRI is used more and more frequently and has proven to be very useful in translational research. In this article, an overview of current preclinical research applications and trends of SPECT combined with CT or MRI, mainly in tumour imaging and neuroscience imaging, is given and the advantages and disadvantages of the different approaches are described. Today SPECT and CT systems are often integrated into a single device commonly called a SPECT-CT system, whereas at present combined SPECT and MRI is almost always carried out with separate systems and fiducial markers to combine the separately acquired images. While preclinical SPECT-CT is most widely applied in oncology research, SPECT combined with MRI SPECT-MRI when integrated in one system offers the potential for both neuroscience applications and oncological applications. Today CT and MRI are still mainly used to localize radiotracer binding and to improve SPECT quantification, although both CT and MRI have additional potential. Future technology developments may include fast sequential or simultaneous acquisition of dynamic multimodality data, spectroscopy, fMRI along with high-resolution anatomic MRI, advanced CT procedures, and combinations of more than two modalities such as combinations of SPECT, PET, MRI and CT all together. This will all strongly depend on new technologies. With further advances in biology and chemistry for imaging molecular targets and pathophysiological processes in vivo, the introduction of new imaging procedures and promising new radiopharmaceuticals in clinical practice may be accelerated.

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Autor: Monique R. Bernsen - Pieter E. B. Vaissier - Roel Van Holen - Jan Booij - Freek J. Beekman - Marion de Jong


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