Anticancer Activity of Ferulic Acid-Inorganic Nanohybrids Synthesized via Two Different Hybridization Routes, Reconstruction and Exfoliation-ReassemblyReport as inadecuate

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The Scientific World JournalVolume 2013 2013, Article ID 421967, 9 pages

Research Article

Department of Chemistry and Medical Chemistry, College of Science and Technology, Yonsei University, Wonju, Gangwon-do 220-710, Republic of Korea

Department of Biosystems and Biomaterials Science and Engineering, College of Agriculture and Life Sciences, Seoul National University, Seoul 151-921, Republic of Korea

RandI Korea, GBU SC, Solvay, Industry-University Cooperation Building, Ewha Womans University, 150 Bukahyun-ro, Seodaemun-gu, Seoul 120-750, Republic of Korea

National Institute of Horticultural and Herbal Science NIHHS of RDA, Eumseong-gun, Chungcheongbuk-do 369-873, Republic of Korea

Received 31 August 2013; Accepted 26 September 2013

Academic Editors: K. Liu and H. E. Unalan

Copyright © 2013 Hyoung-Jun Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We have successfully prepared nanohybrids of biofunctional ferulic acid and layered double hydroxide nanomaterials through reconstruction and exfoliation-reassembly routes. From X-ray diffraction and infrared spectroscopy, both nanohybrids were determined to incorporate ferulic acid molecules in anionic form. Micrsocopic results showed that the nanohybrids had average particle size of 150 nm with plate-like morphology. As the two nanohybridization routes involved crystal disorder and random stacking of layers, the nanohybrids showed slight alteration in -axis crystallinity and particle size. The zeta potential values of pristine and nanohybrids in deionized water were determined to be positive, while those in cell culture media shifted to negative values. According to the in vitro anticancer activity test on human cervical cancer HeLa cells, it was revealed that nanohybrids showed twice anticancer activity compared with ferulic acid itself. Therefore we could conclude that the nanohybrids of ferulic acid and layered double hydroxide had cellular delivery property of intercalated molecules on cancer cell lines.

Author: Hyoung-Jun Kim, Kitae Ryu, Joo-Hee Kang, Ae-Jin Choi, Tae-il Kim, and Jae-Min Oh



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