Microenvironment-induced myofibroblast-like conversion of engrafted keratinocytes - Download this document for free, or read online. Document in PDF available to download.

Science China Life Sciences

, Volume 57, Issue 2, pp 209–220

First Online: 17 January 2014Received: 11 August 2013Accepted: 12 September 2013DOI: 10.1007-s11427-014-4613-6

Cite this article as: Li, M., Ti, D., Han, W. et al. Sci. China Life Sci. 2014 57: 209. doi:10.1007-s11427-014-4613-6

Abstract

Myofibroblasts, recognized classically by α-smooth muscle actin α-SMA expression, play a key role in the wound-healing process, promoting wound closure and matrix deposition. Although a body of evidence shows that keratinocytes explanted onto a wound bed promote closure of a skin injury, the underlying mechanisms are not well understood. The basal layer of epidermis is rich in undifferentiated keratinocytes UKs. We showed that UKs injected into granulation tissue could switch into α-SMA positive cells, and accelerate the rate of skin wound healing. In addition, when the epidermis sheets isolated from foreskin cover up the wound bed or are induced in vitro, keratinocytes located at the basal layers or adjacent sites were observed to convert into myofibroblast-like cells. Thus, UKs have a potential for myofibroblastic transition, which provides a novel mechanism by which keratinocyte explants accelerate skin wound healing.

Keywordsepithelial-mesenchymal transition epithelial-myofibroblast transition keratinocyte-myofibroblast transition myofibroblast wound healing This article is published with open access at link.springer.com

Electronic Supplementary MaterialSupplementary material is available for this article at 10.1007-s11427-014-4613-6 and is accessible for authorized users.

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Author: MeiRong Li - DongDong Ti - WeiDong Han - XiaoBing Fu

Source: https://link.springer.com/

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