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Radiation Oncology

, 9:218

Clinical Radiation Oncology


Yomo and Hayashi reported results of stereotactic radiosurgery alone for brainmetastases from small cell lung cancer. This strategy aims to avoid theneurocognitive effects of whole-brain radiation therapy. However, radiosurgeryalone increases the risk of distant intracranial relapse, which canindependently worsen cognition. This concern is heightened in histologies likesmall cell with high predilection for intracranial spread. The majority of studypatients developed new brain disease, suggesting radiosurgery alone may not bean optimal strategy for preserving neurocognitive function in this population.We suggest whole-brain radiation therapy should remain the standard of care forsmall cell lung cancer.

KeywordsSmall cell lung cancer Stereotactic radiosurgery Whole-brain radiation therapy Neurocognitive Prophylactic cranial irradiation AbbreviationsSRSStereotactic radiosurgery

SCLCSmall-cell lung cancer

WBRTWhole-brainradiation therapy.

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Autor: Eric Ojerholm - Michelle Alonso-Basanta - Charles B Simone II


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