The Evaluation of Diastolic Dysfunction with Tissue Doppler Echocardiography in Women with Subclinical Hypothyroidism and the Effect of L-Thyroxine Treatment on Diastolic Dysfunction: A Pilot StudyReportar como inadecuado




The Evaluation of Diastolic Dysfunction with Tissue Doppler Echocardiography in Women with Subclinical Hypothyroidism and the Effect of L-Thyroxine Treatment on Diastolic Dysfunction: A Pilot Study - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Journal of Thyroid ResearchVolume 2011 2011, Article ID 654304, 7 pages

Research Article

Department of Gastroenterology, Faculty of Medicine, Ufuk University Hospital, 06520 Ankara, Turkey

Department of Cardiology, Faculty of Medicine, Ufuk University Hospital, 06520 Ankara, Turkey

Department of Cardiology, Faculty of Medicine, Gazi University Hospital, 06500 Ankara, Turkey

Department of Internal Medicine, Ankara Numune Education and Research Hospital, 06640 Ankara, Turkey

Department of Endocrinology, Ankara Guven Hospital, 06540 Ankara, Turkey

Received 20 March 2011; Revised 12 May 2011; Accepted 19 June 2011

Academic Editor: Duncan Topliss

Copyright © 2011 Gulbanu Erkan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Subclinical hypothyroidism SH predominantly affects women. The necessity of treatment in SH is controversial. Objective. We aimed to investigate the response of diastolic dysfunction to thyroid hormone replacement therapy THRT in women. Methods and Results. Twenty-two female subjects with SH and 20 euthyroid female controls were enrolled. Baseline and follow-up biochemical, hormonal, and echocardiographic evaluations were performed. Repeat echocardiograms were performed three months after the achievement of a euthyroid status with THRT. Mean baseline myocardial performance index MPI was in the SH group, and in the control group . MPI did not change significantly after THRT. Pulsed-wave Doppler findings were not different among the groups. However, tissue Doppler-derived mitral annular E’ velocities were significantly lower in the SH group. A moderate but significant improvement was observed in E’ velocities after THRT versus , . We also observed left ventricular concentric remodeling in SH patients which was reversible with THRT. Conclusions. Tissue Doppler echocardiography may be a useful tool for monitoring the response of diastolic dysfunction to thyroid hormone replacement therapy in patients with SH. Our findings suggest that THRT may reverse diastolic dysfunction in women with SH.





Autor: Gulbanu Erkan, Aycan Fahri Erkan, Mustafa Cemri, Selma Karaahmetoglu, Mustafa Cesur, and Atiye Cengel

Fuente: https://www.hindawi.com/



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