Paracrine signaling in stem cell renewal and in neoplastic tumor growthReportar como inadecuado




Paracrine signaling in stem cell renewal and in neoplastic tumor growth - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Science China Life Sciences

, Volume 57, Issue 6, pp 571–574

First Online: 21 May 2014Received: 15 February 2014Accepted: 02 April 2014DOI: 10.1007-s11427-014-4664-8

Cite this article as: Zhao, C. Sci. China Life Sci. 2014 57: 571. doi:10.1007-s11427-014-4664-8

Abstract

Paracrine pathway activities are being increasingly recognized as instrumental regulatory mechanisms of epithelial-stromal interactions that play important roles in physiological and pathological self-renewal of stem cells and in the initiation and maintenance of neoplastic tumor development. Stromal-specific Hedgehog Hh responses and epithelial-associated Wnt pathway activities have been recently appreciated as important factors in stem cell self-renewal and carcinogenesis. Furthermore, Hh and Wnt pathways frequently crosstalk with each other to regulate the growth of epithelial cells in a context-dependent manner. Because small molecule modulators of Hh and Wnt pathway activities are readily available, emerging roles of Hh-Wnt pathway crosstalk in epithelial-stromal interactions will shed light on the development of regenerative and anticancer medicines.

KeywordsHedgehog Wnt paracrine stem cell tumor This article is published with open access at link.springer.com

Download to read the full article text



Autor: Chen Zhao

Fuente: https://link.springer.com/







Documentos relacionados