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Disease Markers - Volume 25 2008, Issue 1, Pages 59-65



Centre for Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany

St. Josefs Hospital, Freiburg, Germany

Received 12 August 2008; Accepted 12 August 2008

Copyright © 2008 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Toll like receptors TLRs are an essential part of the innate immune response. So far, ten different TLRs were identified in humans. They recognize a wide range of microbial and viral pathogens. Infection by respiratory syncytial virus RSV is still a major health problem, about 2% of all children are hospitalised due to RSV bronchiolitis during their first 2 years of live. TLR4 has already been described in association with RSV associated diseases by us and others.

Thus we were interested whether other TLRs are also involved in the genetics of severe RSV infection. We genotyped 19 polymorphisms in the autosomal TLRs, these are TLR1, 2, 3, 5, 6, 9 and 10. Association analyses by the Armitage-s Trend test revealed weak association of one TLR9 promoter polymorphism with RSV infection p = 0.013. In addition, association was found with TLR10 haplotypes p = 0.024.

We conclude from our data – that – although we can not rule out a minor involvement of TLR9 polymorphism and TLR10 haplotypes – TLRs other than TLR4 do not play a major role in the genetics of severe RSV associated diseases. Future studies should focus on additional genes of the innate immune response.





Autor: Beena Mailaparambil, Marcus Krueger, Jessica Heinze, Johannes Forster, and Andrea Heinzmann

Fuente: https://www.hindawi.com/



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