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Thyroid Research

, 7:11

First Online: 05 December 2014Received: 17 June 2014Accepted: 01 December 2014DOI: 10.1186-s13044-014-0011-1

Cite this article as: Ayaz, T., Sahin, S.B., Sahin, O.Z. et al. Thyroid Res 2014 7: 11. doi:10.1186-s13044-014-0011-1


ObjectiveThe cell-mediated immune process by CD4+ and CD8+ lymphocyte subsets of T-cells has a major role in the pathogenesis of Hashimoto’s thyroiditis HT. However, the exact mechanisms of initiation and progression of thyroid autoimmunity have not been completely clarified yet. Macrophage migration inhibitory factor MIF is commonly recognized as playing vital roles in various autoimmune diseases. Ee aimed to investigate serum MIF levels in subjects with HT and correlate them with the level of thyroid hormones and autoantibodies.

Materials and methodsThis study included 93 patients with untreated Hashimoto’s thyroiditis and 53 healthy controls. We measured serum levels of TSH, free T4 FT4, free T3 FT3, anti-thyroglobulin autoantibody TGAb and anti-thyroid peroxidase autoantibody TPOAb in all patients and thyroid ultrasonography was performed. The concentration of MIF was measured using enzyme-linked immunosorbent assay ELISA method.

ResultsWe enrolled 93 patients with HT mean age; 31.3 ± 11.1 years, and 53 healthy control group mean age; 29.3 ± 8.5 years in the current study. The patient group consisted of 52 with euthyroid autoimmune thyroiditis, 31 with subclinical hypothyroidism and 10 with overt hypothyroidism. Serum levels of MIF were higher in patients with overt hypothyroidism 6300.9 ± 2504.3 pg-ml than the euthyroid patients 3955.2 ± 3013.6 pg-ml p = 0.036.

ConclusionMIF increases in overt hypothyroidism due to the Hashimoto’s thyroiditis. Further investigations are needed to explore the role of MIF in pathogenesis of Hashimoto’s thyroiditis.

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Autor: Teslime Ayaz - Serap Baydur Sahin - Osman Zikrullah Sahin - Medine Cumhur Cure - Fatih Sumer - Kadir Ilkkilic


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