Scallop protein with endogenous high taurine and glycine content prevents high-fat, high-sucrose-induced obesity and improves plasma lipid profile in male C57BL-6J miceReportar como inadecuado




Scallop protein with endogenous high taurine and glycine content prevents high-fat, high-sucrose-induced obesity and improves plasma lipid profile in male C57BL-6J mice - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Amino Acids

, Volume 46, Issue 7, pp 1659–1671

First Online: 23 March 2014Received: 06 December 2013Accepted: 25 February 2014DOI: 10.1007-s00726-014-1715-1

Cite this article as: Tastesen, H.S., Keenan, A.H., Madsen, L.
et al.
Amino Acids 2014 46: 1659.
doi:10.1007-s00726-014-1715-1

Abstract

High-protein diets induce alterations in metabolism that may prevent diet-induced obesity.
However, little is known as to whether different protein sources consumed at normal levels may affect diet-induced obesity and associated co-morbidities.
We fed obesity-prone male C57BL-6J mice high-fat, high-sucrose diets with protein sources of increasing endogenous taurine content, i.e., chicken, cod, crab and scallop, for 6 weeks.
The energy intake was lower in crab and scallop-fed mice than in chicken and cod-fed mice, but only scallop-fed mice gained less body and fat mass.
Liver mass was reduced in scallop-fed mice, but otherwise no changes in lean body mass were observed between the groups.
Feed efficiency and apparent nitrogen digestibility were reduced in scallop-fed mice suggesting alterations in energy utilization and metabolism.
Overnight fasted plasma triacylglyceride, non-esterified fatty acids, glycerol and hydroxy-butyrate levels were significantly reduced, indicating reduced lipid mobilization in scallop-fed mice.
The plasma HDL-to-total-cholesterol ratio was higher, suggesting increased reverse cholesterol transport or cholesterol clearance in scallop-fed mice in both fasted and non-fasted states.
Dietary intake of taurine and glycine correlated negatively with body mass gain and total fat mass, while intake of all other amino acids correlated positively.
Furthermore taurine and glycine intake correlated positively with improved plasma lipid profile, i.e., lower levels of plasma lipids and higher HDL-to-total-cholesterol ratio.
In conclusion, dietary scallop protein completely prevents high-fat, high-sucrose-induced obesity whilst maintaining lean body mass and improving the plasma lipid profile in male C57BL-6J mice.

KeywordsCholesterol Diet-induced obesity Plasma lipid profile Protein Seafood Taurine Electronic supplementary materialThe online version of this article doi:10.1007-s00726-014-1715-1 contains supplementary material, which is available to authorized users.

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Autor: Hanne Sørup Tastesen - Alison H. Keenan - Lise Madsen - Karsten Kristiansen - Bjørn Liaset

Fuente: https://link.springer.com/



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