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Science China Life Sciences

, Volume 57, Issue 7, pp 672–680

First Online: 26 June 2014Received: 21 May 2014Accepted: 13 June 2014DOI: 10.1007-s11427-014-4694-2

Cite this article as: Wang, J. & Xiao, R. Sci. China Life Sci. 2014 57: 672. doi:10.1007-s11427-014-4694-2


G-protein coupled receptors GPCRs compromise the largest membrane protein superfamily which play vital roles in physiological and pathophysiological processes including energy homeostasis. Moreover, they also represent the up-to-date most successful drug target. The gut hormone GPCRs, such as glucagon receptor and GLP-1 receptor, have been intensively studied for their roles in metabolism and respective drugs have developed for the treatment of metabolic diseases such as type 2 diabetes T2D. Along with the advances of biomedical research, more GPCRs have been found to play important roles in the regulation of energy homeostasis from nutrient sensing, appetite control to glucose and fatty acid metabolism with various mechanisms. The investigation of their biological functions will not only improve our understanding of how our body keeps the balance of energy intake and expenditure, but also highlight the possible drug targets for the treatment of metabolic diseases. The present review summarizes GPCRs involved in the energy control with special emphasis on their pathophysiological roles in metabolic diseases and hopefully triggers more intensive and systematic investigations in the field so that a comprehensive network control of energy homeostasis will be revealed, and better drugs will be developed in the foreseeable future.

KeywordsG-protein coupled receptor energy homeostasis metabolism This article is published with open access at link.springer.com

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Autor: Jue Wang - RuiPing Xiao

Fuente: https://link.springer.com/

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