Reactivity of Monoclonal Antibodies Directed against Lung Cancer Antigens with Human Lung, Breast and Colon Cancer Cell LinesReport as inadecuate




Reactivity of Monoclonal Antibodies Directed against Lung Cancer Antigens with Human Lung, Breast and Colon Cancer Cell Lines - Download this document for free, or read online. Document in PDF available to download.

Disease Markers - Volume 11 1993, Issue 5-6, Pages 225-237



Human Morphology, University of Southampton, UK

Division of Oncology, University Hospital Zürich, Zürich, Switzerland

Received 24 January 1994

Copyright © 1993 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A panel of monoclonal antibodies n=72 including controls directed against lung cancer antigens was screened immunohistochemically against a panel of seven human lung cancer cell lines including small cell carcinoma, squamous cell carcinoma, adenocarcinoma and mesothelioma, six human breast cancer cell lines and one human colon cancer cell line, The majority of the antibodies n=42 reacted also with antigens present on breast and colon cancer cell lines, This cross reactivity especially between lung and breast cancer cell lines is not altogether unexpected since antigens common to breast and lung tissue including their neoplasms such as MUC1 antigen have been described, Our results indicate that epitopes shared by lung and breast cancers are probably more common than previously thought. The relevance for prognosis and therapy of these shared antigens, especially as disease markers in breast cancer, has to be investigated.





Author: Udo Schumacher, Dhia Mukthar, and Thomas Schenker

Source: https://www.hindawi.com/



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