Genotypic distribution of human papillomavirus HPV and cervical cytology findings in 5906 Thai women undergoing cervical cancer screening programsReportar como inadecuado




Genotypic distribution of human papillomavirus HPV and cervical cytology findings in 5906 Thai women undergoing cervical cancer screening programs - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Infectious Agents and Cancer

, 10:7

First Online: 02 March 2015Received: 22 November 2014Accepted: 30 January 2015DOI: 10.1186-s13027-015-0001-5

Cite this article as: Kantathavorn, N., Mahidol, C., Sritana, N. et al. Infect Agents Cancer 2015 10: 7. doi:10.1186-s13027-015-0001-5

Abstract

BackgroundCervical cancer is the major cause of morbidity and mortality in Thai women. Nevertheless, the preventive strategy such as HPV vaccination program has not been implemented at the national level. This study explored the HPV prevalence and genotypic distribution in a large cohort of Thai women.

MethodsA hospital-based cervical cancer screening program at Chulabhorn Hospital, Bangkok and a population-based screening program at a rural Pathum Thani Province were conducted using liquid-based cytology and HPV genotyping.

ResultsOf 5906 women aged 20–70 years, Pap smear was abnormal in 4.9% and the overall HPV prevalence was 15.1%, with 6.4% high-risk HR, 3.5% probable high-risk PR, and 8.4% low-risk LR HPV. The prevalence and genotypic distribution were not significantly different between the two cohorts. Among HR-HPV genotypes, HPV52 was the most frequent 1.6%, followed by HPV16 1.4%, HPV51 0.9%, HPV58 0.8%, HPV18 0.6%, and HPV39 0.6%. Among LR-HPV genotypes, HPV72 and HPV62 were the most frequent while HPV6 and HPV11 were rare. HPV infection was found to be proportionately high in young women, aged 20–30 years 25% and decreasing with age 11% in women aged >50. The more severe abnormal cytology results, the higher positivity of HR-HPV infection was observed.

ConclusionsIn conclusion, HPV52, HPV16, and HPV51 were identified as the most common HR-HPV genotypes in Thai women. This study contributes genotypic evidence that should be essential for the development of appropriate HPV vaccination program as part of Thailand’s cervical cancer prevention strategies.

KeywordsCervical cancer Cancer screening HPV genotypes Cervical cytology Thailand AbbreviationsASC-HAtypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion

ASC-USAtypical squamous cells of undetermined significance

ASRAge standardized incidence rate

CINCervical intraepithelial neoplasia CIN

HPVHuman papillomavirus

HRHigh risk

HSILHigh grade squamous intraepithelial lesion

LRLow risk

LSILLow grade squamous intraepithelial lesion

NCINational Cancer Institute

PCRPolymerase chain reaction

PRProbable high risk

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Autor: Nuttavut Kantathavorn - Chulabhorn Mahidol - Narongrit Sritana - Thaniya Sricharunrat - Natacha Phoolcharoen - Chirayu Auewa

Fuente: https://link.springer.com/



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