Lack of an Association between Neutrophil-to-Lymphocyte Ratio and PSA Failure of Prostate Cancer Patients Who Underwent Radical ProstatectomyReport as inadecuate

Lack of an Association between Neutrophil-to-Lymphocyte Ratio and PSA Failure of Prostate Cancer Patients Who Underwent Radical Prostatectomy - Download this document for free, or read online. Document in PDF available to download.

BioMed Research International - Volume 2016 2016, Article ID 6197353, 6 pages -

Research Article

Departments of Urology and Renal Transportation, Yokohama City University Medical Center, Yokohama 2320024, Japan

Department of Urology, Yokohama City University, Graduate School of Medicine, Yokohama 2360004, Japan

Departments of Pathology and Urology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA

Received 15 December 2015; Revised 15 March 2016; Accepted 5 April 2016

Academic Editor: Mario Scartozzi

Copyright © 2016 Yoko Maeda et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. The neutrophil-to-lymphocyte ratio NLR, which can be easily calculated from routine complete blood counts of the peripheral blood, has been suggested to serve as a prognostic factor for some solid malignancies. In the present study, we aimed to determine the relationship between NLR in prostate cancer patients undergoing radical prostatectomy RP and their prognosis. Materials and Methods. We assessed NLR in 73 men patients who received RP for their prostate cancer. We also performed immunohistochemistry for CD8 and CD66b in a separate set of RP specimens. Results. The median NLR in the 73 patients was 1.85. There were no significant correlations of NLR with tumor grade , pathological T stage , lymph node metastasis , or resection margin status . Based on the area under the receiver operator characteristic curve AUROC to predict biochemical recurrence after RP, potential NLR cut-off point was determined to be 2.88 or 3.88. However, both of these cut-off points did not precisely predict the prognosis. There were no statistically significant differences in the number of CD66b-positive neutrophils or CD8-positive lymphocytes between stromal tissues adjacent to cancer glands and stromal tissues away from cancer glands and between different grades or stages of tumors. Conclusions. There was no association between NLR and biochemical failure after prostatectomy.

Author: Yoko Maeda, Takashi Kawahara, Mitsuyuki Koizumi, Hiroki Ito, Yohei Kumano, Mari Ohtaka, Takuya Kondo, Taku Mochizuki, Yusu



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