The MNS16A polymorphism in the TERT gene in peri-centenarians from the Han Chinese populationReport as inadecuate

The MNS16A polymorphism in the TERT gene in peri-centenarians from the Han Chinese population - Download this document for free, or read online. Document in PDF available to download.

Science China Life Sciences

, Volume 57, Issue 10, pp 1024–1027

First Online: 12 September 2014Received: 25 November 2013Accepted: 07 May 2014DOI: 10.1007-s11427-014-4723-1

Cite this article as: Liu, L., Wang, C., Lu, X. et al. Sci. China Life Sci. 2014 57: 1024. doi:10.1007-s11427-014-4723-1


MNS16A, a variable number of tandem repeats polymorphism in the TERT gene, has been suggested to regulate telomerase activity. As telomerase activity has been reported to be related to life-span, we hypothesized that this polymorphism might affect human longevity by controlling the length of the telomere. To test this hypothesis, we collected 446 unrelated pericentenarian individuals age⩾90, mean 94.45±3.45 years and 332 normal controls age 22–53, mean 35.0±12.0 years from Dujiangyan, Sichuan, China. We typed the MNS16A polymorphism in both groups, and compared the allele and genotype frequencies between the peri-centenarian and control groups using the chi-squared test. There was no significant difference between the peri-centenarian and control groups. Thus, the MNS16A polymorphism in TERT might not influence human life-span, at least in the Han Chinese population studied here.

Keywordstelomerase longevity MNS16A polymorphism peri-centenarian Contributed equally to this work

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Author: LiNa Liu - ChengYe Wang - Xiang Lu - FuHui Xiao - HuaWei Wang - LiQin Yang - LiangYou Xu - QingPeng Kong


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