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Hereditary Cancer in Clinical Practice

, 13:11

First Online: 08 April 2015Received: 09 June 2014Accepted: 18 March 2015DOI: 10.1186-s13053-015-0032-3

Cite this article as: Hall, M.J., Ruth, K.J., Chen, D.Y. et al. Hered Cancer Clin Pract 2015 13: 11. doi:10.1186-s13053-015-0032-3


BackgroundAdvancements in genomic testing have led to the identification of single nucleotide polymorphisms SNPs associated with prostate cancer. The clinical utility of SNP tests to evaluate prostate cancer risk is unclear. Studies have not examined predictors of interest in novel genomic SNP tests for prostate cancer risk in a diverse population.

MethodsConsecutive participants in the Fox Chase Prostate Cancer Risk Assessment Program PRAP n = 40 and unselected men from surgical urology clinics n = 40 completed a one-time survey. Items examined interest in genomic SNP testing for prostate cancer risk, knowledge, impact of unsolicited findings, and psychosocial factors including health literacy.

ResultsKnowledge of genomic SNP tests was low in both groups, but interest was higher among PRAP men p < 0.001. The prospect of receiving unsolicited results about ancestral genomic markers increased interest in testing in both groups. Multivariable modeling identified several predictors of higher interest in a genomic SNP test including higher perceived risk p = 0.025, indicating zero reasons for not wanting testing vs ≥1 reason p = 0.013, and higher health literacy p = 0.016.

ConclusionsKnowledge of genomic SNP testing was low in this sample, but higher among high-risk men. High-risk status may increase interest in novel genomic tests, while low literacy may lessen interest.

KeywordsGenomic testing Health literacy Prostate cancer Risk assessment Single-nucleotide polymorphism AbbreviationsAAAfrican American

FCCCFox Chase Cancer Center

FDRFirst-degree relative

NGSNext-generation sequencing

PRAPProstate Risk Assessment Program

PSAProstate Specific Antigen

SNPSingle Nucleotide Polymorphism

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Author: Michael J Hall - Karen J Ruth - David YT Chen - Laura M Gross - Veda N Giri


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