Assessment of pharmacological activities of two medicinal plant of Bangladesh: Launaea sarmentosa and Aegialitis rotundifolia roxb in the management of pain, pyrexia and inflammationReportar como inadecuado




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Biological Research

, 47:55

First Online: 28 October 2014Received: 08 September 2014Accepted: 11 October 2014DOI: 10.1186-0717-6287-47-55

Cite this article as: Raju, G.S., RahmanMoghal, M.M., Hossain, M.S. et al. biol res 2014 47: 55. doi:10.1186-0717-6287-47-55

Abstract

BackgroundThe current study aims at evaluating the analgesic, anti-pyretic and anti-inflammatory properties of methanolic extract of the stem, bark and leaves of Launaea sarmentosa and Aegialitis rotundifolia roxb.

ResultsThe AELS and AEAR extract presented a significant ***p < 0.001 dose dependent increase in reaction time in writhing method and showed inhibition of 63.1% and 57.1% respectively at the doses of 400 mg-kg body weight while standard drug showed P < 0.001 inhibition of 69.23%. In tail immersion method, AELS and AEAR showed maximum time of tail retention at 30 min in hot water i.e. 6.93 sec and 6.54 sec respectively at highest doses of 400 mg-kg body weight than lower dose while standard pentazocine showed reaction time of 7.62 sec. The AELS and AEAR extract also exhibited promising anti-inflammatory effect as demonstrated by statistically significant inhibition of paw volume by 32.48% and 26.75% respectively at the dose of 400 mg-kg body weight while the value at the dose of 200 mg-kg body weight were linear to higher dose at the 3 hour of study. On the other hand, Standard indomethacin inhibited 40.13% of inflammation ***P < 0.001. In Cotton-pellet granuloma method, AELS and AEAR extract at the dose of 400 mg-kg body weight exhibited inhibition of inflammation of 34.7% and 29.1% respectively while standard drug showed P < 0.001 inhibition of 63.22%. Intraperitoneal administration of AELS and AEAR showed dose dependent decrease in body temperature in brewer’s yeast induced hyperthermia in rats at both doses. However, AELS significantly decreased body temperature ***p < 0.001 at 400 mg-kg compared to control.

ConclusionsPresent work propose that the methanolic extract of Launaea sarmentosa and Aegialitis rotundifolia roxb possesses dose dependent pharmacological action which supports its therapeutic use in folk medicine possibly mediated through the inhibition or blocking of release of prostaglandin and-or actions of vasoactive substances such as histamine, serotonin and kinins.

KeywordsLaunaea sarmentosa Aegialitis rotundifolia roxb Analgesic Antipyretic Anti-inflammatory AbbreviationsAELSAqueous extract of Launaea sarmentosa

AEARAqueous extract of Aegialitis rotundifolia roxb

COXCyclooxygenase

LOXLipoxygenase

NSAIDNon-steroidal anti-inflammatory drugs.

Electronic supplementary materialThe online version of this article doi:10.1186-0717-6287-47-55 contains supplementary material, which is available to authorized users.

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Autor: Golam Sarwar Raju - Md Mizanur RahmanMoghal - Mohammad Salim Hossain - Md Mahadi Hassan - Md Mustahsan Billah - Sayed K

Fuente: https://link.springer.com/







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