The Effect of Multidisciplinary Lifestyle Intervention on the Pre- and Postprandial Plasma Gut Peptide Concentrations in Children with ObesityReportar como inadecuado




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ISRN EndocrinologyVolume 2011 2011, Article ID 353756, 7 pages

Research Article

Department of Pediatrics, Juliana Children-s Hospital-Haga Hospital, Sportlaan 600, 2566 MJ the Hague, The Netherlands

Department of Endocrinology and Metabolism, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands

Department of Pediatrics, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands

Department of Medical Statistics, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands

Received 12 March 2011; Accepted 12 April 2011

Academic Editors: C. Anderwald and W. B. Chan

Copyright © 2011 Rimke C. Vos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. This study aims to evaluate the effect of a multidisciplinary treatment of obesity on plasma concentrations of several gut hormones in fasting condition and in response to a mixed meal in children. Methods. Complete data were available from 36 obese children age 1 3 . 3 ± 2 . 0  yr. At baseline and after the 3-month multidisciplinary treatment, fasting and postprandial blood samples were taken for glucose, insulin, ghrelin, peptide YY PYY, and glucagon-like peptide 1 GLP-1. Results. BMI-SDS was significantly reduced by multidisciplinary treatment from 4 . 2 ± 0 . 7 to 4 . 0 ± 0 . 9 , 𝑃 < . 0 1 . The intervention significantly increased the area under the curve AUC of ghrelin from 9 2 . 3 ± 1 8 . 3 to 9 7 . 9 ± 1 8 . 2 pg-L, 𝑃 < . 0 1 , but no significant changes were found for PYY or GLP-1 concentrations in fasting or postprandial condition. The insulin resistance index HOMA-IR remained unchanged as well. Conclusion. Intensive multidisciplinary treatment induced moderate weight loss and increased ghrelin secretion, but serum PYY and GLP-1 concentrations and insulin sensitivity remained unchanged.





Autor: Rimke C. Vos, Hanno Pijl, Jan M. Wit, Erik W. van Zwet, Chris van der Bent, and Euphemia C. A. M. Houdijk

Fuente: https://www.hindawi.com/



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