Putative roles of purinergic signaling in human immunodeficiency virus-1 infectionReportar como inadecuado

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Biology Direct

, 9:21

Systems Biology


ReviewersThis article was reviewed by Neil S. Greenspan and Rachel Gerstein.

Nucleotides and nucleosides act as potent extracellular messengers via the activation of the family of cell-surface receptors termed purinergic receptors. These receptors are categorized into P1 and P2 receptors P2Rs. P2Rs are further classified into two distinct families, P2X receptors P2XRs and P2Y receptors P2YRs. These receptors display broad tissue distribution throughout the body and are involved in several biological events. Immune cells express various P2Rs, and purinergic signaling mechanisms have been shown to play key roles in the regulation of many aspects of immune responses. Researchers have elucidated the involvement of these receptors in the host response to infections. The evidences indicate a dual function of these receptors, depending on the microorganism and the cellular model involved. Three recent reports have examined the relationship between the level of extracellular ATP, the mechanisms underlying purinergic receptors participating in the infection mechanism of HIV-1 in the cell. Although preliminary, these results indicate that purinergic receptors are putative pharmacological targets that should be further explored in future studies.

KeywordsP2X7R HIV-1 infection Antagonists Pharmacological targets  Download fulltext PDF

Autor: Paulo AF Pacheco - Robson X Faria - Leonardo GB Ferreira - Izabel CNP Paixão

Fuente: https://link.springer.com/

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