Applicability of Isolates and Fractions of Plant Extracts in Murine Models in Type II Diabetes: A Systematic ReviewReportar como inadecuado

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Evidence-Based Complementary and Alternative Medicine - Volume 2016 2016, Article ID 3537163, 25 pages -

Review Article

Department of Medicine and Nursing, Federal University of Viçosa, Viçosa, MG, Brazil

Institute of Biomedical Science, Department of Structural Biology, Federal University of Alfenas, Alfenas, MG, Brazil

Department of General Biology, Federal University of Viçosa, Viçosa, MG, Brazil

Department of Animal Biology, Federal University of Viçosa, MG, Brazil

Received 16 March 2016; Accepted 11 May 2016

Academic Editor: Mohammed S. Razzaque

Copyright © 2016 Gabriela Diniz Pinto Coelho et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Type II diabetes mellitus is one of the most common public health problems worldwide. Its increasing prevalence in several countries and the difficult metabolic control of individuals with the disease justify studying strategies for primary prevention. The population has sought alternative and cheaper ways to treat the disease, including the use of plants considered medicinal by the population. In this study, we carried out a systematic review on the applicability of isolates and fractions of plant extracts in animal models in type II diabetes. A literature search was performed in MEDLINE-PubMed and Scopus databases. Studies using other experimental animals horses, rabbits, and monkeys and humans as well as articles in Chinese, German, and Russian were excluded. We assessed the quality of the studies included by using the criteria described in the ARRIVE guidelines. In general, the animals that received fractions or isolates presented reduced blood glucose levels, normalization of body weight and plasma insulin levels, and reduced total triglycerides and cholesterol. In addition, we observed wide variation among the analyzed parameters, which hindered comparison between the studies found. In further studies, standardized reports and experimental design would help to establish comparable study groups and advance the overall knowledge, thus facilitating translatability from animal data to human clinical conditions.

Autor: Gabriela Diniz Pinto Coelho, Vanessa Soares Martins, Laura Vieira do Amaral, Rômulo Dias Novaes, Mariáurea Matias Sarandy, 



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