Alternative Paradigm of Selective Vagus Nerve Stimulation Tested on an Isolated Porcine Vagus NerveReportar como inadecuado

Alternative Paradigm of Selective Vagus Nerve Stimulation Tested on an Isolated Porcine Vagus Nerve - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

The Scientific World Journal - Volume 2014 2014, Article ID 310283, 10 pages -

Research ArticleITIS d.o.o. Ljubljana, Center for Implantable Technology and Sensors, Lepi Pot 11, 1000 Ljubljana, Slovenia

Received 26 August 2013; Accepted 2 October 2013; Published 6 February 2014

Academic Editors: D. J. Moore and A. K. Moschovakis

Copyright © 2014 Polona Pečlin and Janez Rozman. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Alternative paradigm for spatial and fibre-type selective vagus nerve stimulation VNS was developed using realistic structural topography and tested in an isolated segment of a porcine cervical left vagus nerve LVN. A spiral cuff cuff containing a matrix of ninety-nine electrodes was developed for selective VNS. A quasitrapezoidal stimulating pulse stimulus was applied to the LVN via an appointed group of three electrodes triplet. The triplet and stimulus were configured to predominantly stimulate the B-fibres, minimizing stimulation of the A-fibres and by-passing the stimulation of the C-fibres. To assess which fibres made the most probable contribution to the neural response NR during selective VNS, the distribution of conduction velocity CV within the LVN was considered. Experimental testing of the paradigm showed the existence of certain parameters and waveforms of the stimulus, for which the contribution of the A-fibres to the NR was slightly reduced and that of the B-fibres was slightly enlarged. The cuff provided satisfactory fascicle discrimination in selective VNS as well as satisfactory fascicle discrimination during NR recording. However, in the present stage of development, fibre-type VNS remained rather limited.

Autor: Polona Pečlin and Janez Rozman



Documentos relacionados