Diagnostic, therapeutic and evolutionary characteristics of cervical cancer in Department of Radiotherapy, Mohamed V Military Hospital – Rabat in MoroccoReportar como inadecuado




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Gynecologic Oncology Research and Practice

, 2:2

First Online: 27 July 2015Received: 06 February 2015Accepted: 05 May 2015DOI: 10.1186-s40661-015-0009-y

Cite this article as: Elmarjany, M., Maghous, A., Razine, R.
et al.
gynaecol oncol res pract 2015 2: 2.
doi:10.1186-s40661-015-0009-y

Abstract

BackgroundCancer of uterine cervix is the second most common cause of cancer related deaths among women.
The aim of this study is to report the experience of Military Hospital Mohamed V in the management of cervical cancer and their results.

MethodsAll cervical cancer managed at the radiotherapy department of Military Hospital Mohamed V between January 2005 and February 2010, were included for investigation of their demographic, histological, therapeutic and follow-up characteristics.
Of the 162 cases managed, 151 93.2 % cases were treated in our department.

ResultsIn our study the median age was 51.5 years 33–82.
The median duration of symptoms before diagnosis was four 3, 7 months.
The major presenting complaints were abnormal vaginal bleeding 89.8 %.
Squamous cell carcinoma cervix was seen in 86.2 % n = 137, adenocarcinoma in 11.3 % n = 18 and adenosquamous carcinoma in 2.4 % n = 4.
One hundred seventeen 84.8 % cases were seen at late stage.
An abdominal and pelvic computed tomography CT scan was performed in 34.6 % n = 56 of cases, magnetic resonance imaging MRI in 62.9 % n = 102.
The pelvic lymph nodes were achieved in 16.6 % of cases.

Over half of patients 58.3 % n = 88 were treated with a combination of external beam radiation therapy EBRT and a concurrent cisplatin based chemotherapy 40 mg -m2 weekly.

With a mean of 51.6 months 2 to 109, we recorded 19 12.6 % pelvic relapse and 15 9.9 % metastases.
The median time to onset was 19.4 months 2–84 months.
The local control rate was 63.6 % n = 96 and 21 13.9 % patients were lost to follow-up.
The overall survival OS at 3 years and 5 years was respectively 78.3 % and 73.6 % and the relapse-free survival RFS was respectively 80 % and 77.2 %.

ConclusionMost of cervical cancer patients in Morocco are seen at late stage necessitating referral for radiotherapy, chemotherapy or palliative care.
This may reflect lack of cervical screening in order to early detect and treat pre-malignant disease stage.

KeywordsCancer of uterine cervix Radiotherapy Concomitant radio-chemotherapy  Download fulltext PDF



Autor: Mohammed Elmarjany - Abdelhak Maghous - Rachid Razine - Elamin Marnouche - Khalid Andaloussi - Amine Bazine - Issam Lalya -

Fuente: https://link.springer.com/



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