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Science China Life Sciences

, Volume 58, Issue 1, pp 48–53

First Online: 07 December 2014Received: 17 August 2014Accepted: 21 October 2014DOI: 10.1007-s11427-014-4774-3

Cite this article as: Pan, Z. & Ma, J. Sci. China Life Sci. 2015 58: 48. doi:10.1007-s11427-014-4774-3

Abstract

Store-operated Ca entry SOCE controls intracellular Ca homeostasis and regulates a wide range of cellular events including proliferation, migration and invasion. The discovery of STIM proteins as Ca sensors and Orai proteins as Ca channel pore forming units provided molecular tools to understand the physiological function of SOCE. Many studies have revealed the pathophysiological roles of Orai and STIM in tumor cells. This review focuses on recent advances in SOCE and its contribution to tumorigenesis. Altered Orai and-or STIM functions may serve as biomarkers for cancer prognosis, and targeting the SOCE pathway may provide a novel means for cancer treatment.

KeywordsOrai1 STIM1 Ca oscillations proliferation metastasis oncogenic This article is published with open access at link.springer.com

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Autor: Zui Pan - JianJie Ma

Fuente: https://link.springer.com/







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