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Science China Life Sciences

, Volume 58, Issue 1, pp 28–38

First Online: 10 January 2015Received: 15 August 2014Accepted: 02 September 2014DOI: 10.1007-s11427-014-4788-x

Cite this article as: Buraei, Z., Lumen, E., Kaur, S. et al. Sci. China Life Sci. 2015 58: 28. doi:10.1007-s11427-014-4788-x


Voltage-gated calcium channels VGCCs play critical roles in cardiac and skeletal muscle contractions, hormone and neurotransmitter release, as well as slower processes such as cell proliferation, differentiation, migration and death. Mutations in VGCCs lead to numerous cardiac, muscle and neurological disease, and their physiological function is tightly regulated by kinases, phosphatases, G-proteins, calmodulin and many other proteins. Fifteen years ago, RGK proteins were discovered as the most potent endogenous regulators of VGCCs. They are a family of monomeric GTPases Rad, Rem, Rem2, and Gem-Kir, in the superfamily of Ras GTPases, and they have two known functions: regulation of cytoskeletal dynamics including dendritic arborization and inhibition of VGCCs. Here we review the mechanisms and molecular determinants of RGK-mediated VGCC inhibition, the physiological impact of this inhibition, and recent evidence linking the two known RGK functions.

Keywordscalcium channel modulation trafficking cardiac physiology neurobiology beta subunit This article is published with open access at link.springer.com

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Autor: Zafir Buraei - Ellie Lumen - Sukhjinder Kaur - Jian Yang

Fuente: https://link.springer.com/

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