The predictive role of NLR and PLR for solid non-AIDS defining cancer incidence in HIV-infected subjects: a MASTER cohort studyReportar como inadecuado




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Infectious Agents and Cancer

, 10:34

Clinical oncology

Abstract

BackgroundThe neutrophil to lymphocyte ratio NLR and platelet to lymphocyte ratio PLR, two low cost, routinely available inflammatory indices, have been found to be associated with risk of death in patients with solid cancer, in both general population and HIV-positive subjects. However, no study investigated the role of NLR and PLR as predictive of cancer incidence so far.

MethodsThe aim of our study was to assess the association of PLR and NLR with risk of developing solid non-AIDS defining cancer NADC in HIV-infected subjects. We conducted a multicenter Italian cohort study from 2000 to 2012 including HIV-infected subjects naïve at antiretroviral treatment at enrollment. The associations of NLR and PLR with NADC incidence were evaluated by univariate and multivariate analyses using both time independent and time dependent Cox proportional hazard models.

ResultsThirteen thousand five hundred fifty-nine patients 73.3 % males with a mean age of 36.0 years SD 10.0 were included. The median inter-quartile range of NLR and PLR at baseline were 1.47 1.03–2.17 and 109.9 79.6–155.3, respectively. During a median follow-up of 3.9 years, 337 subjects had a first diagnosis of solid NADC. The crude and age- and gender-standardized incidence rates were 3.57 and 3.91 per 1000 person-years, respectively. No statistically significant association was found between NLR and PLR and NADC incidence, using multivariate models, including also time-dependent Cox models with a cubic-spline for NLR and PLR.

ConclusionThis study does not sustain the hypothesis that NRL and PLR may be useful for predicting the risk of cancer in HIV positive subjects.

KeywordsCancer HIV Inflammation-based biomarkers NLR PLR AbbreviationsNLRNeutrophils to lymphocytes ratio

PLRPlatelet to lymphocytes ratio

NADCNon-AIDS defining cancer

ADCAIDS defining cancer

ARTAntiretroviral therapy

ICDInternational classification of diseases

HRHazards ratio

SDStandard deviation

Electronic supplementary materialThe online version of this article doi:10.1186-s13027-015-0032-y contains supplementary material, which is available to authorized users.

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Autor: Elena Raffetti - Francesco Donato - Francesco Castelli - Franco Maggiolo - Giampiero Carosi - Eugenia Quiros-Roldan

Fuente: https://link.springer.com/



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