Unrelated cord blood transplantation for adult patients with acute myeloid leukemia: higher incidence of acute graft-versus-host disease and lower survival in male patients transplanted with female unrelated cord blood—a report Reportar como inadecuado




Unrelated cord blood transplantation for adult patients with acute myeloid leukemia: higher incidence of acute graft-versus-host disease and lower survival in male patients transplanted with female unrelated cord blood—a report - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Journal of Hematology and Oncology

, 8:107

First Online: 06 October 2015Received: 16 July 2015Accepted: 28 September 2015DOI: 10.1186-s13045-015-0207-4

Cite this article as: Baron, F., Labopin, M., Ruggeri, A. et al. J Hematol Oncol 2015 8: 107. doi:10.1186-s13045-015-0207-4

Abstract

BackgroundIn the setting of allogeneic human leukocyte antigen HLA-matched bone marrow transplantation, transplanting male patients with grafts from female donors has been associated with a higher incidence of graft-versus-host disease GVHD and of nonrelapse mortality NRM. The aim of the current analysis was to compare transplantation outcomes in male patients given female unrelated cord blood UCB versus other gender combinations.

Patients and methodsData from 552 consecutive patients with acute myeloid leukemia AML given a single UCB transplantation between 2000 and 2014 were included.

ResultsIn comparison with other gender combination, male patients given female UCB n = 131 had a trend for a higher incidence of grades II–IV acute GVHD 33 versus 25 %, P = 0.08, a trend for a higher incidence of NRM 41 versus 33 %, P = 0.06, and a lower leukemia-free LFS, 30 versus 41 %, P = 0.01 and overall survival OS, 33 versus 45 %, P = 0.008. In multivariate analyses, taking into consideration all patients for which data on HLA-matching and cell dose transplanted were fully available n = 363, male patients transplanted with a female UCB had a trend for a higher incidence of grade III–IV acute GVHD hazard ratio HR = 2.0, P = 0.06, a trend for a higher NRM HR = 1.5, P = 0.06, and a worse LFS HR = 1.4, P = 0.04 and OS HR = 1.3, P = 0.06.

ConclusionsOur data suggest that male patients transplanted with female UCB might have higher risk of acute GVHD and of NRM leading to worse LFS and OS. These results should be confirmed in other large cohorts of patients before used for determining the choice of an UCB unit.

KeywordsUnrelated cord blood Female Male AML GVHD Transplantation Electronic supplementary materialThe online version of this article doi:10.1186-s13045-015-0207-4 contains supplementary material, which is available to authorized users.

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Autor: Frédéric Baron - Myriam Labopin - Annalisa Ruggeri - Mohamad Mohty - Guillermo Sanz - Noel Milpied - Andrea Bacigalupo -

Fuente: https://link.springer.com/







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