111InPSMA-IandT: expanding the spectrum of PSMA-IandT applications towards SPECT and radioguided surgeryReportar como inadecuado

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EJNMMI Research

, 5:68

First Online: 25 November 2015Received: 23 September 2015Accepted: 17 November 2015DOI: 10.1186-s13550-015-0147-6

Cite this article as: Schottelius, M., Wirtz, M., Eiber, M. et al. EJNMMI Res 2015 5: 68. doi:10.1186-s13550-015-0147-6


BackgroundThe relevance of prostate-specific membrane antigen PSMA targeting in the clinical management of prostate cancer PCa is continually increasing, entailing the development of PSMA-targeted molecular probes. Recently, a first PSMA-targeted theranostic concept has been successfully implemented by Ga-LuPSMA-IandT. To further exploit the excellent PSMA-targeting characteristics and in vivo performance of the PSMA-IandT platform, InPSMA-IandT was evaluated as a complementary probe for radioguided surgery and SPECT imaging.

FindingsCompared to Ga-LuPSMA-IandT, InPSMA-IandT showed unchangedly high PSMA-affinity and enhanced internalization into PSMA-expressing LNCaP PCa cells. Biodistribution studies in LNCaP xenograft-bearing mice 1 h p.i. revealed slightly reduced background accumulation of InPSMA-IandT compared to LuPSMA-IandT and identical tumor uptake of both compounds, leading to increased tumor-background ratios for InPSMA-IandT. An exemplary patient with metastatic PCa underwent preoperative GaHBED-CC-PSMA PET-CT 1 h p.i. and InPSMA-IandT SPECT-CT 4 h p.i., followed by prostatectomy and radioguided extended pelvic lymphadenectomy 24 h p.i

In InPSMA-IandT SPECT-CT, the previously identified PCa lesions GaHBED-CC-PSMA PET-CT showed high tracer accumulation and were also detectable using planar scintigraphy. The intraoperative use of a hand-held gamma probe allowed detection and resection of all InPSMA-IandT-accumulating lesions. The presence of PSMA-positive tumor tissue in the resected specimens was confirmed histopathologically and via InPSMA-IandT autoradiography.

ConclusionsInPSMA-IandT shows efficient PSMA targeting in vitro and in vivo, combined with low background accumulation. In an exemplary PCa patient, InPSMA-IandT was successfully applied for preoperative SPECT-CT visualization and radioguided resection of PSMA-positive lesions, hinting towards a high value of InPSMA-IandT as a complementary tool to Ga-LuPSMA-IandT in the clinical management of prostate cancer.

KeywordsProstate-specific membrane antigen PSMA PSMA-IandT Imaging PET SPECT In Lu Targeted radionuclide therapy Radioguided surgery  Download fulltext PDF

Autor: Margret Schottelius - Martina Wirtz - Matthias Eiber - Tobias Maurer - Hans-Jürgen Wester

Fuente: https://link.springer.com/

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