SIADH-related hyponatremia in hospital day care units: clinical experience and management with tolvaptanReportar como inadecuado

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Supportive Care in Cancer

, Volume 24, Issue 1, pp 499–507

First Online: 02 October 2015Received: 12 May 2015Accepted: 14 September 2015DOI: 10.1007-s00520-015-2948-6

Cite this article as: De las Peñas, R., Ponce, S., Henao, F. et al. Support Care Cancer 2016 24: 499. doi:10.1007-s00520-015-2948-6


Hyponatremia Na ˂135 mmol-l is the most frequent electrolyte disorder in clinical practice, and the syndrome of inappropriate antidiuretic hormone secretion SIADH is the commonest cause of hyponatremia in cancer patients. Correcting hyponatremia in these patients can reduce morbidity and mortality, increase the response to anti-cancer agents, and help reduce hospital length of stay and costs. Tolvaptan is an oral medication used to treat SIADH-related hyponatremia patients that needs to be initiated at hospital so patients can have their serum sodium monitored. If tolvaptan could be initiated in hospital day care units DCUs, performing the same tests, hospitalization could be avoided, quality of life improved, and costs reduced. This is the first publication where a panel of oncologists are sharing their experience and making some recommendations with the use of tolvaptan to treat SIADH-related hyponatremia in DCU after collecting and examining 35 clinical cases with these type of patients. The conclusion from this retrospective observational analysis is that the use of tolvaptan in DCU is safe and effective in the therapeutic management of SIADH-related hyponatremia.

KeywordsAntidiuretic hormone receptor antagonists Day care units Hyponatremia Inappropriate ADH syndrome Tolvaptan Camps, Carcereny, Escobar, Rodriquez and Virizuela contributed equally to this work.

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Autor: Ramón De las Peñas - Santiago Ponce - Fernando Henao - Carlos Camps Herrero - Enric Carcereny - Yolanda Escobar Álvarez


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