Molecular evolution and expression profile of the chemerine encoding gene RARRES2 in baboon and chimpanzeeReportar como inadecuado




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Biological Research

, 48:31

First Online: 12 June 2015Received: 04 November 2014Accepted: 27 May 2015DOI: 10.1186-s40659-015-0020-0

Cite this article as: González-Alvarez, R., Garza-Rodríguez, M

L., Delgado-Enciso, I. et al. Biol Res 2015 48: 31. doi:10.1186-s40659-015-0020-0

Abstract

BackgroundChemerin, encoded by the retinoic acid receptor responder 2 RARRES2 gene is an adipocytesecreted protein with autocrine-paracrine functions in adipose tissue, metabolism and inflammation with a recently described function in vascular tone regulation, liver, steatosis, etc. This molecule is believed to represent a critical endocrine signal linking obesity to diabetes. There are no data available regarding evolution of RARRES2 in non-human primates and great apes. Expression profile and orthology in RARRES2 genes are unknown aspects in the biology of this multigene family in primates. Thus; we attempt to describe expression profile and phylogenetic relationship as complementary knowledge in the function of this gene in primates. To do that, we performed A RT-PCR from different tissues obtained during necropsies. Also we tested the hypotheses of positive evolution, purifying selection, and neutrality. And finally a phylogenetic analysis was made between primates RARRES2 protein.

ResultsRARRES2 transcripts were present in liver, lung, adipose tissue, ovary, pancreas, heart, hypothalamus and pituitary tissues. Expression in kidney and leukocytes were not detectable in either species. It was determined that the studied genes are orthologous.

ConclusionsRARRES2 evolution fits the hypothesis of purifying selection. Expression profiles of the RARRES2 gene are similar in baboons and chimpanzees and are also phylogenetically related.

KeywordsRetinoic acid receptor Responder protein Primate Chemerin TIG2 Tazarotene-induced gene 2 protein Gene expression AbbreviationsRARRES2Retinoic acid receptor responder protein 2

OWMOld World primates

T2DMType 2 diabetes mellitus

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Autor: Rafael González-Alvarez - María de Lourdes Garza-Rodríguez - Iván Delgado-Enciso - Víctor Manuel Treviño-Alvarado - R

Fuente: https://link.springer.com/



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