Association of oesophageal radiation dose volume metrics, neutropenia and acute radiation oesophagitis in patients receiving chemoradiotherapy for non-small cell lung cancerReportar como inadecuado




Association of oesophageal radiation dose volume metrics, neutropenia and acute radiation oesophagitis in patients receiving chemoradiotherapy for non-small cell lung cancer - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Radiation Oncology

, 11:20

Clinical Radiation Oncology

Abstract

IntroductionThe relationship between oesophageal radiation dose volume metrics and dysphagia in patients having chemoradiation CRT for non-small cell lung cancer NSCLC is well established. There is also some evidence that neutropenia is a factor contributing to the severity of oesophagitis. We retrospectively analysed acute radiation oesophagitis ARO rates and severity in patients with NSCLC who received concurrent chemotherapy and high dose radiation therapy CRT. We investigated if there was an association between grade of ARO, neutropenia and radiation dose volume metrics.

Material and methodsPatients with NSCLC having concurrent CRT who had RT dose and toxicity data available were eligible. Exclusion criteria included previous thoracic RT, treatment interruptions and non-standard dose regimens. RT dosimetrics included maximum and mean oesophageal dose, oesophagus dose volume and length data.

ResultsFifty four patients were eligible for analysis. 42 78 % patients received 60 Gy. Forty four 81 % patients received carboplatin based chemotherapy. Forty eight 89 % patients experienced ARO ≥ grade 1 95 % CI: 78 % to 95 %. ARO grade was associated with mean dose rs = 0.27, p = 0.049, V20 rs = 0.31, p = 0.024 and whole oesophageal circumference receiving 20 Gy rs = 0.32 p = 0.019. In patients who received these doses, V20 n = 51, rs = 0.36, p = 0.011, V35 n = 43, rs = 0.34, p = 0.027 and V60 n = 25, rs = 0.59, P = 0.002 were associated with RO grade. Eleven of 25 44 % patients with ARO ≥ grade 2 also had ≥ grade 2 acute neutropenia compared with 5 of 29 17 % patients with RO grade 0 or 1 p = 0.035.

ConclusionIn addition to oesophageal dose-volume metrics, neutropenia may also be a risk factor for higher grades of ARO.

KeywordsLung cancer Neutropenia Oesophagitis Radiation toxicity Radiation therapy  Download fulltext PDF



Autor: Sarah Everitt - Mary Duffy - Mathias Bressel - Belinda McInnes - Christine Russell - Tim Sevitt - David Ball

Fuente: https://link.springer.com/







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