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BMC Cancer

, 16:93

Translational oncology

Abstract

BackgroundThe receptor for advanced glycation endproducts RAGE and microvascular status both play a critical role in cancer progression. However, the crosstalk between RAGE and microvascular formation in endometrial cancer remains largely unknown.

MethodsRAGE expression and microvessel density were examined in 20 cases of normal endometrial tissue, 37 cases of well-differentiated endometrial cancer tissue, and 35 cases of poorly-differentiated endometrial cancer tissue. Regression analysis was used to examine the relationship between RAGE and microvessel density. The knockdown of RAGE was achieved using a small interfering RNA in HEC-1A endometrial cancer cells. A xenografted tumour model was used to evaluate RAGE-mediated microvascular formation and proliferation of endometrial cancer cells.

ResultsIt was shown that i RAGE expression gradually increased in normal endometrium, well-differentiated endometrial cancer, and poorly-differentiated endometrial cancer, respectively; ii a positive correlation existed between RAGE and microvessel density in human endometrial cancer samples; iii RAGE knockdown was effective in decreasing microvessel formation in xenografted tumour models; and iv RAGE knockdown can significantly inhibit the proliferation of endometrial cancer cells in vivo.

ConclusionsThese results indicate that RAGE may be a potential trigger in microvascular formation and proliferation in the development of endometrial cancer.

KeywordsRAGE Microvascular Proliferation Endometrial cancer AbbreviationsAGEsadvanced glycation endproducts

RAGEreceptor for advanced glycation endproducts

siRNAsmall interfering RNA

Electronic supplementary materialThe online version of this article doi:10.1186-s12885-016-2126-3 contains supplementary material, which is available to authorized users.

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Autor: Lu Zheng - Da Li - Yi-Ming Zhou - Hui Yang - Di Cheng - Xiao-Xin Ma

Fuente: https://link.springer.com/







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