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Chinese Journal of Cancer

, 35:19

Tumor Angiogenesis

Abstract

Directed capillary ingrowth has long been considered synonymous with tumor vascularization. However, the vasculature of primary tumors and metastases is not necessarily formed by endothelial cell sprouting; instead, malignant tumors can acquire blood vessels via alternative vascularization mechanisms, such as intussusceptive microvascular growth, vessel co-option, and glomeruloid angiogenesis. Importantly, in response to anti-angiogenic therapies, malignant tumors can switch from one vascularization mechanism to another. In this article, we briefly review the biological features of these mechanisms and discuss on their significance in medical oncology.

KeywordsVascularization Primary tumor Metastasis Angiogenesis Edina Bugyik and Ferenc Renyi-Vamos contributed equally as first authors to this study

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Autor: Edina Bugyik - Ferenc Renyi-Vamos - Vanessza Szabo - Katalin Dezso - Nora Ecker - Andras Rokusz - Peter Nagy - Balazs Dome

Fuente: https://link.springer.com/







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