Organic Cation Transporter 1 OCT1 mRNA expression in hepatocellular carcinoma as a biomarker for sorafenib treatmentReportar como inadecuado




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BMC Cancer

, 16:94

Translational oncology

Abstract

BackgroundThe polyspecific organ cation transporter 1 OCT1 is one of the most important active influx pumps for drugs like the kinase inhibitor sorafenib. The aim of this retrospective study was the definition of the role of intratumoral OCT1 mRNA expression in hepatocellular carcinoma HCC as a biomarker in systemic treatment with sorafenib.

MethodsOCT1 mRNA expression levels were determined in biopsies from 60 primary human HCC by real time PCR. The data was retrospectively correlated with clinical parameters.

ResultsIntratumoral OCT1 mRNA expression is a significant positive prognostic factor for patients treated with sorafenib according to Cox regression analysis HR 0.653, 95 %-CI 0.430-0.992; p = 0.046. Under treatment with sorafenib, a survival benefit could be shown using the lower quartile of intratumoral OCT1 expression as a cut-off. Macrovascular invasion MVI was slightly more frequent in patients with low OCT1 mRNA expression p = 0.037. Treatment-induced AFP response was not associated with intratumoral OCT1 mRNA expression levels p = 0.633.

ConclusionsThis study indicates a promising role for intratumoral OCT1 mRNA expression as a prognostic biomarker in therapeutic algorithms in HCC. Further prospective studies are warranted on this topic.

KeywordsHepatocellular carcinoma HCC OCT1 SLC22A1 Biomarker Sorafenib AbbreviationsMVImacrovascular invasion

EHSextrahepatic spread

AFPalpha-fetoprotein

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Autor: Daniel Grimm - Jonas Lieb - Veronika Weyer - Johanna Vollmar - Felix Darstein - Anja Lautem - Maria Hoppe-Lotichius - Sandr

Fuente: https://link.springer.com/







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