Relapse of both small cell lung cancer and Lambert–Eaton myasthenic syndrome after a 13-year disease-free survival periodReportar como inadecuado




Relapse of both small cell lung cancer and Lambert–Eaton myasthenic syndrome after a 13-year disease-free survival period - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Chinese Journal of Cancer

, 35:63

First Online: 02 July 2016Received: 19 November 2015Accepted: 10 March 2016DOI: 10.1186-s40880-016-0127-x

Cite this article as: Asano, F., Watanabe, K., Shinkai, M. et al. Chin J Cancer 2016 35: 63. doi:10.1186-s40880-016-0127-x

Abstract

Lambert–Eaton myasthenic syndrome LEMS is a paraneoplastic syndrome and only 3% of small cell lung carcinoma SCLC patients have LEMS. Moreover, the recurrence of SCLC after a disease-free survival DFS of more than 10 years is rare. We report a patient who had a recurrence of both SCLC and LEMS after a 13-year DFS period. A 69-year-old man was diagnosed with LEMS and SCLC cT0N2M0, stage IIIA 13 years ago. Chemoradiotherapy was performed and a complete response was achieved. With anticancer treatment, the LEMS symptoms was alleviated. At the age of 82 years, gait disturbance appeared followed by left supraclavicular lymphadenopathy and further examination revealed the recurrence of SCLC. Careful screening for the recurrence of SCLC might be needed when the patient has recurrent or secondary paraneoplastic neurological syndrome even after a long DFS period.

KeywordsLambert–Eaton myasthenic syndrome Paraneoplastic syndrome Paraneoplastic neurological syndrome P-Q-type anti-voltage-gated calcium channel antibody Small cell lung carcinoma  Download fulltext PDF



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Fuente: https://link.springer.com/



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