Maternal nutrition modulates fetal development by inducing placental efficiency changes in giltsReport as inadecuate

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BMC Genomics

, 18:213



BackgroundIntra-uterine growth restriction IUGR and fetal overgrowth increase risks to postnatal health. Maternal nutrition is the major intrauterine environmental factor that alters fetal weight. However, the mechanisms underlying the effects of maternal nutrition on fetal development are not entirely clear. We developed a pig model, and using isobaric tags for relative and absolute quantification iTRAQ, we investigated alterations in the placental proteome of gilts on a normal-energy-intake Con and high-energy-intake HE diet.

ResultsIn the Con group, heavy and light fetuses were found at the tubal and cervical ends of the uterus respectively at 90 d of gestation. Moreover, the heavy fetuses had a higher glucose concentration than the light fetuses. However, a higher uniformity was noted in the HE group. Placental promoters between these two positions indicated that 78 and 50 differentially expressed proteins were detected in the Con and HE groups respectively. In the Con group, these proteins were involved in lipid metabolism HADHA, AACS, CAD, nutrient transport GLUT, SLC27A1, and energy metabolism NDUFV1, NDUFV2, ATP5C1. However, in the HE group they mainly participated in transcriptional and translational regulation, and intracellular vesicular transport.

ConclusionsOur findings revealed that maternal nutrition may alter birth weight mainly through the modulation of placental lipid and energy metabolism, which also provides a possible mechanism to explain the higher uniformity of fetal weight in gilts fed a HE diet.

KeywordsEnergy level Gilts Fetal weight Placenta iTRAQ AbbreviationsAACSAcyl-CoA synthetase

ABCB7ATP-binding cassette sub-family B member 7

ACSF2Acyl-CoA synthetase family member 2

ATP5C1ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1

C6SChondroitin 6-sulfate

CADAcyl-CoA dehydrogenase


CVBW0Within-litter variation of piglet birth weight

CYP3A46Cytochrome P450 3A46

EIF5BEukaryotic translation initiation factor 5B


FUCA1Fucosidase, alpha-L-1


GLUTGlucose transport protein

GOGene ontology

HADHAMitochondrial trifunctional protein


HSD17B1417-beta-hydroxysteroid dehydrogenase 14

iTRAQIsobaric tags for relative and absolute quantification

IUGRIntra-uterine growth restriction

LCFALong chain fatty acids

MGLLMonoglyceride lipase

NDUFV1NADH dehydrogenase ubiquinone flavoprotein 1

NDUFV2NADH dehydrogenase ubiquinone flavoprotein 2

RPL2360S ribosomal protein L23a

RPS2540S ribosomal protein S25

SLC27A1Solute carrier family 27

Electronic supplementary materialThe online version of this article doi:10.1186-s12864-017-3601-1 contains supplementary material, which is available to authorized users.

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Author: Long Che - ZhenGuo Yang - MengMeng Xu - ShengYu Xu - LianQiang Che - Yan Lin - ZhengFeng Fang - Bin Feng - Jian Li - DaiW


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