Evaluation of tumour hypoxia during radiotherapy using 18FHX4 PET imaging and blood biomarkers in patients with head and neck cancerReportar como inadecuado




Evaluation of tumour hypoxia during radiotherapy using 18FHX4 PET imaging and blood biomarkers in patients with head and neck cancer - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

European Journal of Nuclear Medicine and Molecular Imaging

, Volume 43, Issue 12, pp 2139–2146

First Online: 01 June 2016Received: 18 March 2016Accepted: 19 May 2016DOI: 10.1007-s00259-016-3429-y

Cite this article as: Zegers, C.M.L., Hoebers, F.J.P., van Elmpt, W. et al. Eur J Nucl Med Mol Imaging 2016 43: 2139. doi:10.1007-s00259-016-3429-y

Abstract

Background and purposeIncreased tumour hypoxia is associated with a worse overall survival in patients with head and neck squamous cell carcinoma HNSCC. The aims of this study were to evaluate treatment-associated changes in FHX4-PET, hypoxia-related blood biomarkers, and their interdependence.

Material and methodsFHX4-PET-CT scans of 20 patients with HNSCC were acquired at baseline and after ±20Gy of radiotherapy. Within the gross-tumour-volumes GTV; primary and lymph nodes, mean and maximum standardized uptake values, the hypoxic fraction HF and volume HV were calculated. Also, the changes in spatial uptake pattern were evaluated using FHX4-PET-CT imaging. For all patients, the plasma concentration of CAIX, osteopontin and VEGF was assessed.

ResultsAt baseline, tumour hypoxia was detected in 69 % 22-32 of the GTVs. During therapy, we observed a significant decrease in all image parameters. The HF decreased from 21.7 ± 19.8 % baseline to 3.6 ± 10.0 % during treatment; P < 0.001. Only two patients had a HV > 1 cm during treatment, which was located for >98 % within the baseline HV. During treatment, no significant changes in plasma CAIX or VEGF were observed, while osteopontin was increased.

ConclusionsFHX4-PET-CT imaging allows monitoring changes in hypoxia during chemoradiotherapy whereas the blood biomarkers were not able to detect a treatment-associated decrease in hypoxia.

KeywordsHypoxia PET CAIX Osteopontin VEGF Electronic supplementary materialThe online version of this article doi:10.1007-s00259-016-3429-y contains supplementary material, which is available to authorized users.

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