18F-alfatide PET-CT may predict short-term outcome of concurrent chemoradiotherapy in patients with advanced non-small cell lung cancerReportar como inadecuado




18F-alfatide PET-CT may predict short-term outcome of concurrent chemoradiotherapy in patients with advanced non-small cell lung cancer - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

European Journal of Nuclear Medicine and Molecular Imaging

, Volume 43, Issue 13, pp 2336–2342

First Online: 08 September 2016Received: 06 June 2016Accepted: 25 August 2016DOI: 10.1007-s00259-016-3505-3

Cite this article as: Luan, X., Huang, Y., Gao, S. et al. Eur J Nucl Med Mol Imaging 2016 43: 2336. doi:10.1007-s00259-016-3505-3

Abstract

PurposeThe study aims to investigate the role of F-alfatide positron emission tomography-computed tomography PET-CT in predicting the short-term outcome of concurrent chemoradiotherapy CCRT in patients with advanced non-small cell lung cancer NSCLC.

MethodsEighteen patients with advanced NSCLC had undergone F-alfatide PET-CT scans before CCRT and PET-CT parameters including maximum and mean standard uptake values SUVmax-SUVmean, peak standard uptake values SUVpeak and tumor volume TVPET and TVCT were obtained. The SUVmax of tumor and normal tissues lung, blood pool and muscle were measured, and their ratios were denoted as T-NT T-NTlung, T-NTblood and T-NTmuscle. Statistical methods included the Two-example t test, Wilcoxon rank-sum test, Receiver-operating characteristic ROC curve analysis and logistic regression analyses.

ResultsWe found that SUVmax, SUVpeak, T-NTlung, T-NTblood and T-NTmuscle were higher in non-responders than in responders P = 0.0024, P = 0.016, P < 0.001, P = 0.003, P = 0.004. According to ROC curve analysis, the thresholds of SUVmax, SUVpeak, T-NTlung, T-NTblood and T-NTmuscle were 5.65, 4.46, 7.11, 5.41, and 11.75, respectively. The five parameters had high sensitivity, specificity and accuracy in distinguishing non-responders and responders. Multivariate logistic regression analyses showed that T-NTlung was an independent predictor of the short-term outcome of CCRT in patients with advanced NSCLC P = 0.032.

ConclusionsF-alfatide PET-CT may be useful in predicting the short-term outcome of CCRT in patients with advanced NSCLC.

KeywordsNon-small cell lung cancer Concurrent Chemoradiotherapy F-alfatide PET-CT Integrin αvβ3  Download fulltext PDF



Autor: Xiaohui Luan - Yong Huang - Song Gao - Xiaorong Sun - Suzhen Wang - Li Ma - Xuepeng Teng - Hong Lu - Jinming Yu - Shuangh

Fuente: https://link.springer.com/







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