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Biology Direct

, 11:45

Structural and Molecular Biology

AbstractIntrinsically disordered regions IDRs of proteins fulfill important regulatory roles in most organisms. However, the proteins of certain endosymbiont and intracellular pathogenic bacteria with extremely reduced genomes contain disproportionately small amounts of IDRs, consisting almost entirely of folded domains. As their genomes co-evolving with their hosts have been reduced in unrelated lineages, the proteomes of these bacteria represent independently evolved minimal protein sets. We systematically analyzed structural disorder in a representative set of such minimal organisms to see which types of functionally relevant longer IDRs are invariably retained in them. We found that a few characteristic functions are consistently linked with conformational disorder: ribosomal proteins, key components of the protein production machinery, a central coordinator of DNA metabolism and certain housekeeping chaperones seem to strictly rely on structural disorder even in genome-reduced organisms. We propose that these functions correspond to the most essential and probably also the most ancient ones fulfilled by structural disorder in cellular organisms.

ReviewersThis article was reviewed by Michael Gromiha, Zoltan Gaspari and Sandor Pongor.

KeywordsIntrinsically disordered Structural disorder Genome reduction Endosymbiont Minimal genome Disorder prediction Essential function Genome-reduced bacterium Chaperone function AbbreviationsATPAdenosine triphosphate

GTPGuanosine triphosphate

Hsp70Seat shock protein 70

IDPIntrinsically disordered protein

IDRIntrinsically disordered region

LDRLong disordered region

NMRNuclear magnetic resonance

PDBProtein Data Bank

PIRProtein information resource

SSBSingle stranded DNA binding protein

ssDNASingle stranded DNA

Electronic supplementary materialThe online version of this article doi:10.1186-s13062-016-0149-y contains supplementary material, which is available to authorized users.

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Autor: Rita Pancsa - Peter Tompa


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