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BMC Genomics

, 17:891

Non-human and non-rodent vertebrate genomics

Abstract

BackgroundConsumers are becoming increasingly conscientious about the nutritional value of their food. Consumption of some fatty acids has been associated with human health traits such as blood pressure and cardiovascular disease. Therefore, it is important to investigate genetic variation in content of fatty acids present in meat. Previously publications reported regions of the cattle genome that are additively associated with variation in fatty acid content. This study evaluated epistatic interactions, which could account for additional genetic variation in fatty acid content.

ResultsEpistatic interactions for 44 fatty acid traits in a population of Angus beef cattle were evaluated with EpiSNPmpi. False discovery rate FDR was controlled at 5 % and was limited to well-represented genotypic combinations. Epistatic interactions were detected for 37 triacylglyceride TAG, 36 phospholipid PL fatty acid traits, and three weight traits. A total of 6,181, 7,168, and 0 significant epistatic interactions FDR < 0.05, 50-animals per genotype combination were associated with Triacylglyceride fatty acids, Phospholipid fatty acids, and weight traits respectively and most were additive-by-additive interactions. A large number of interactions occurred in potential regions of regulatory control along the chromosomes where genes related to fatty acid metabolism reside.

ConclusionsMany fatty acids were associated with epistatic interactions. Despite a large number of significant interactions, there are a limited number of genomic locations that harbored these interactions. While larger population sizes are needed to accurately validate and quantify these epistatic interactions, the current findings point towards additional genetic variance that can be accounted for within these fatty acid traits.

KeywordsEpistatic interaction Beef cattle Fatty acids Triacylglyceride Phospholipid AbbreviationsTAGTriacylglyceride

PLPhospholipid

SFASaturated Fatty Acid

MUFAMonounsaturated Fatty Acid

PUFAPolyunsaturated Fatty Acid

GOGene Ontology

SNPSingle Nucleotide Polymorphism

MAFMinor Allele Frequency

Electronic supplementary materialThe online version of this article doi:10.1186-s12864-016-3235-8 contains supplementary material, which is available to authorized users.

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Autor: L. M. Kramer - M. A. Abdel Ghaffar - J. E. Koltes - E. R. Fritz-Waters - M. S. Mayes - A. D. Sewell - N. T. Weeks -

Fuente: https://link.springer.com/



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