Between-species differences in gene copy number are enriched among functions critical for adaptive evolution in Arabidopsis halleriReportar como inadecuado

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BMC Genomics

, 17:1034

First Online: 22 December 2016DOI: 10.1186-s12864-016-3319-5

Cite this article as: Suryawanshi, V., Talke, I.N., Weber, M. et al. BMC Genomics 2016 17Suppl 13: 1034. doi:10.1186-s12864-016-3319-5


BackgroundGene copy number divergence between species is a form of genetic polymorphism that contributes significantly to both genome size and phenotypic variation. In plants, copy number expansions of single genes were implicated in cultivar- or species-specific tolerance of high levels of soil boron, aluminium or calamine-type heavy metals, respectively. Arabidopsis halleri is a zinc- and cadmium-hyperaccumulating extremophile species capable of growing on heavy-metal contaminated, toxic soils. In contrast, its non-accumulating sister species A. lyrata and the closely related reference model species A. thaliana exhibit merely basal metal tolerance.

ResultsFor a genome-wide assessment of the role of copy number divergence CND in lineage-specific environmental adaptation, we conducted cross-species array comparative genome hybridizations of three plant species and developed a global signal scaling procedure to adjust for sequence divergence. In A. halleri, transition metal homeostasis functions are enriched twofold among the genes detected as copy number expanded. Moreover, biotic stress functions including mostly disease Resistance R gene-related genes are enriched twofold among genes detected as copy number reduced, when compared to the abundance of these functions among all genes.

ConclusionsOur results provide genome-wide support for a link between evolutionary adaptation and CND in A. halleri as shown previously for Heavy metal ATPase4. Moreover our results support the hypothesis that elemental defences, which result from the hyperaccumulation of toxic metals, allow the reduction of classical defences against biotic stress as a trade-off.

KeywordsCross-species Array-CGH Metal hyperaccumulation CNV Arabidopsis halleri Toll-Interleukin Receptor-Nucleotide Binding Site-Leucine Rich Repeat TIR-NBS-LRR protein family Resistance genes R genes Electronic supplementary materialThe online version of this article doi:10.1186-s12864-016-3319-5 contains supplementary material, which is available to authorized users.

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Autor: Vasantika Suryawanshi - Ina N. Talke - Michael Weber - Roland Eils - Benedikt Brors - Stephan Clemens - Ute Krämer


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