Integration of Intention and Outcome for Moral Judgment in Frontotemporal Dementia: Brain Structural SignaturesReportar como inadecuado




Integration of Intention and Outcome for Moral Judgment in Frontotemporal Dementia: Brain Structural Signatures - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Resumen

Background: Moral judgment has been proposed to rely on a distributed brain network. This function is impaired in behavioral variant frontotemporal dementia bvFTD, a condition involving damage to some regions of this network. However, no studies have investigated moral judgment in bvFTD via structural neuroimaging. Methods: We compared the performance of 21 bvFTD patients and 19 controls on a moral judgment task involving scenarios that discriminate between the contributions of intentions and out-comes. Voxel-based morphometry was used to assess a the atrophy pattern in bvFTD patients, b associations between gray matter GM volume and moral judgments, and c structural differences between bvFTD subgroups patients with relatively preserved moral judgment and patients with severer moral judgment impairments. Results: Patients judged attempted harm as more permissible and accidental harm as less permissible than controls. The groups- performance on accidental harm was associated with GM volume in the precuneus. In controls, it was also associated with the ventromedial prefrontal cortex VMPFC. Also, both groups- performance on attempted harm was associated with GM volume in the temporoparietal junction. Patients exhibiting worse performance displayed smaller GM volumes in the precuneus and temporal pole. Conclusions: Results suggest that moral judgment abnormalities in bvFTD are associated with impaired integration of intentions and outcomes, which depends on an extended brain network. In bvFTD, moral judgment seems to critically depend on areas beyond the VMPFC.Indización

Artículo de publicación ISI



Autor: Báez, Sandra; - Kanske, Philipp; - Matallana, Diana; - Montanes, Patricia; - Reyes, Pablo; - Slachevsky Chonchol, Andrea; - Matu

Fuente: http://repositorio.uchile.cl/



DESCARGAR PDF




Documentos relacionados