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Stroke Research and TreatmentVolume 2012 2012, Article ID 156975, 7 pages

Clinical StudyOperative Unit of Vascular Surgery, Department of Surgery, Maggiore Hospital of Bologna, 40133 Bologna, Italy

Received 1 July 2011; Revised 25 August 2011; Accepted 26 August 2011

Academic Editor: Arijana Lovrencic-Huzjan

Copyright © 2012 Luciano Pedrini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Guidelines do not include cerebral oximetry among monitoring for carotid endarterectomy CEA. The purpose of this study was to evaluate the reliability of near-infrared spectroscopy NIRS in the detection of clamping ischemia and in the prevention of clamping-related neurologic deficits using, as a cutoff for shunting, a 20% regional cerebral oxygen saturation rSO2 decrease if persistent more than 4 minutes, otherwise a 25% rSO2 decrease. Bilateral rSO2 was monitored continuously in patients undergoing CEA under general anesthesia GA. Data was recorded after clamping, declamping, during shunting and lowest values achieved. Preoperative neurologic, CT-scan, and vascular lesions were recorded. We reviewed 473 cases: 305 males 64.5% mean age . Three patients presented transient ischemic deficits at awakening, no perioperative stroke or death; 41 8.7% required shunting: 30 based on the initial rSO2 value and 11 due to a decrease during surgery. Using the ROC curve analysis we found, for a >25% reduction from baseline value, a sensitivity of 100% and a specificity of 90.6%. Reliability, PPV, and NPV were 95.38%, 9%, and 100%, respectively. In conclusion, this study indicates the potential reliability of NIRS monitoring during CEA under GA, using a cutoff of 25% or a cutoff of 20% for prolonged hypoperfusion.

Autor: Luciano Pedrini, Filippo Magnoni, Luigi Sensi, Emilio Pisano, Maria Sandra Ballestrazzi, Maria Rosaria Cirelli, and Alessand



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