The health-related quality of life burden of co-morbid cardiovascular disease and major depressive disorder in Australia: findings from a population-based, cross-sectional studyReportar como inadecuado




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Quality of Life Research

, Volume 22, Issue 1, pp 37–44

First Online: 10 February 2012Accepted: 20 January 2012DOI: 10.1007-s11136-012-0128-4

Cite this article as: O’Neil, A., Stevenson, C.E., Williams, E.D. et al. Qual Life Res 2013 22: 37. doi:10.1007-s11136-012-0128-4

Abstract

PurposeHealth-related quality of life HRQOL can be significantly impaired by the presence of chronic conditions such as cardiovascular disease CVD and major depressive disorder MDD. The aim of this paper was to 1 identify differences in HRQOL between individuals with CVD, MDD, or both, compared to a healthy reference group, 2 establish whether the influence of co-morbid MDD and CVD on HRQOL is additive or synergistic and 3 determine the way in which depression severity interacts with CVD to influence overall HRQOL.

MethodsPopulation-based data from the 2007 Australian National Survey of Mental Health and Well-being NSMHWB n = 8841 were used to compare HRQOL of individuals with MDD and CVD, MDD but not CVD, CVD but not MDD, with a healthy reference group. HRQOL was measured using the Assessment of Quality of Life AQOL. MDD was identified using the Composite International Diagnostic Interview CIDI 3.0.

ResultsOf all four groups, individuals with co-morbid CVD and depression reported the greatest deficits in AQOL utility scores Coef: −0.32, 95% CI: −0.40, −0.23, after adjusting for covariates. Those with MDD only Coef: −0.27, 95% CI: −0.30, −0.24 and CVD only Coef: −0.08, 95% CI: −0.11, −0.05 also reported reduced AQOL utility scores. Second, the influence of MDD and CVD on HRQOL was shown to be additive, rather than synergistic. Third, a significant dose–response relationship was observed between depression severity and HRQOL. However, CVD and depression severity appeared to act independently of each other in impacting HRQOL.

ConclusionsHRQOL is greatly impaired in individuals with co-morbid MDD and CVD; these conditions appear to influence HRQOL in an additive fashion. HRQOL alters with depression severity, therefore treating depression and improving HRQOL is of clinical importance.

KeywordsHealth-related quality of life Depression Cardiovascular disease Dose–response Synergistic AbbreviationsCVDCardiovascular disease

MDDMajor Depressive Disorder

MIMyocardial Infarction

CHDCoronary Heart Disease

HRQOLHealth-related quality of life

NSMHWBNational Survey of Mental Health and Well-being

CIDI 3.0Composite International Diagnostic Interview 3.0

AQOL-4DAssessment of Quality of Life

BMIBody Mass Index

SEStandard Errors

CIConfidence Intervals

STROBEStrengthening the Reporting of Observational Studies in Epidemiology

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Autor: Adrienne O’Neil - Christopher E. Stevenson - Emily D. Williams - Duncan Mortimer - Brian Oldenburg - Kristy Sanderson

Fuente: https://link.springer.com/







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